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THE IMPACT OF STATISTICAL METHOD CHOICE: EVALUATION OF THE
SANO RANDOMIZED CLINICAL TRIAL USING TWO NON-TRADITIONAL
STATISTICAL METHODS
by
Christianne Joy Lane
Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PSYCHOLOGY)
August 2009
Copyright 2009 Christianne Joy Lane
Object Description
| Title | The impact of statistical method choice: evaluation of the SANO randomized clinical trial using two non-traditional statistical methods |
| Author | Lane, Christianne Joy |
| Author email | clane@usc.edu; christiannelane@yahoo.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Psychology |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2009-05-11 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-07-07 |
| Advisor (committee chair) | Wilcox, Rand |
| Advisor (committee member) |
Read, Steve Lu, Zhong-Lin Azen, Stanley |
| Abstract | When the findings of a randomized clinical trial are null, and yet the assumptions of the statistical model are not met, is it appropriate to conclude there is not an effect of the intervention? The purpose of this study is to examine statistical method choice for the analysis of a randomized clinical trial of a strength training and nutrition intervention in a sample of overweight Latino adolescents (N = 54). Results of analysis of covariance (ANCOVA) models were overwhelmingly null, however there were several concerns about the underlying assumptions. Two non-traditional statistical approaches that do not carry the same assumptions as traditional ANCOVA were used to reanalyze these data. The first approach uses a robust analog of ANCOVA that is based on fewer restrictions, and which can increase power while maintaining Type I error rate, even with small samples. Using these robust techniques, the conclusions regarding the effectiveness of the intervention varied widely from those of traditional ANCOVA, as several significant intervention effects were found with these robust methods. In the second approach, developed for this study, a hybrid of two common latent profile analysis models was created to generate a profile of which participants benefited from the intervention. This model tests whether the sample is homogeneous. With this model, it was shown that gender and pre-test values had more influence than the intervention on outcomes, and the intervention appeared to modify these influences. These results suggest that the use of traditional ANCOVA models in the face of assumption violations may lead to missing important effects of an intervention. Expanding the scope of standard techniques for analyzing randomized clinical trials would likely result in a different literature landscape for many disciplines, though the acceptability of the use of these results poses challenges for publication of papers using them.; New guidelines may need to be incorporated into recommendations for which methods to use for analyzing randomized clinical trials. |
| Keyword | robust ANCOVA; latent profile analyses; SANO |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2330 |
| Rights | Lane, Christianne Joy |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Lane-2893 |
| Archival file | uscthesesreloadpub_Volume14/etd-Lane-2893.pdf |
Description
| Title | Page 1 |
| Full text | THE IMPACT OF STATISTICAL METHOD CHOICE: EVALUATION OF THE SANO RANDOMIZED CLINICAL TRIAL USING TWO NON-TRADITIONAL STATISTICAL METHODS by Christianne Joy Lane Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PSYCHOLOGY) August 2009 Copyright 2009 Christianne Joy Lane |
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