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THE ROLE OF MICRORNAS IN CANCER
by
Jeffrey Mathew Friedman
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
August 2009
Copyright 2009 Jeffrey Mathew Friedman
Object Description
| Title | The role of microRNAs in cancer |
| Author | Friedman, Jeffrey Mathew |
| Author email | jeffrey.friedman@usc.edu; jeffreymfriedman@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2009-04-07 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-07-05 |
| Advisor (committee chair) | Jones, Peter A. |
| Advisor (committee member) |
Coetzee, Gerhard Laird, Peter |
| Abstract | MicroRNAs (miRNAs) are small non-coding RNAs that are expressed in higher eukaryoates and have even been found in viral genomes. They usually act as endogenous repressors of target genes by either inhibiting translation, causing mRNA degradation, or by a combination of both mechanisms. More than 900 mature miRNA sequences have been identified in humans, and although this accounts for less than 2% of human genes, it is predicted that 30% of mRNAs are targeted by miRNAs. miRNAs play critical roles in most cellular processes including development, differentiation, and the homeostasis of both a cell and an organism. Moreover, many disease states, including cancer, occur or are sustained by miRNA dysregulation. Here we will review the latest reports of miRNA involvement and aberrant expression in human disease with an emphasis on cancer. |
| Keyword | cancer; microRNA; epigenetics; polycomb; EZH2; molecular biology |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2325 |
| Rights | Friedman, Jeffrey Mathew |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Friedman-2888 |
| Archival file | uscthesesreloadpub_Volume48/etd-Friedman-2888.pdf |
Description
| Title | Page 1 |
| Full text | THE ROLE OF MICRORNAS IN CANCER by Jeffrey Mathew Friedman A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOCHEMISTRY AND MOLECULAR BIOLOGY) August 2009 Copyright 2009 Jeffrey Mathew Friedman |
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