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SEARCHING FOR LYMPHOID-SPECIFIC PHOSPHATASE (LYP) INHIBITOR
by
Lei Zhao
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
December 2007
Copyright 2007 Lei Zhao
Object Description
| Title | Searching for lymphoid-specific phosphatase (LYP) inhibitor |
| Author | Zhao, Lei |
| Author email | leizhao@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2007-10-15 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-10-29 |
| Advisor (committee chair) | Tokes, Zoltan |
| Advisor (committee member) |
Frenkel, Baruch Bottini, Nunzio |
| Abstract | Lymphoid-specific protein tyrosine phosphatase (LYP) has been found to be one of the most potent inhibitors of T cell subpopulation activation. A gain-of-function single nucleotide polymorphism (SNP) C1858T has been shown to be involved in several autoimmune diseases. We compared the enzymatic activity of LYP and Pro, Glu, Ser, Thr-rich protein tyrosine phosphatase (PEST). In vitro biochemical studies showed that LYP could differentially hydrolyze several phosphatase substrates. We screened a small molecule library for potential LYP inhibitors. In addition, our siRNA studies confirmed that T-cell receptor signaling was enhanced once LYP expression got repressed. |
| Keyword | autoimmune disease; kinetics; T cell signaling; screening; phosphatase |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m888 |
| Rights | Zhao, Lei |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Zhao-20071029 |
| Archival file | uscthesesreloadpub_Volume44/etd-Zhao-20071029.pdf |
Description
| Title | Page 1 |
| Full text | SEARCHING FOR LYMPHOID-SPECIFIC PHOSPHATASE (LYP) INHIBITOR by Lei Zhao A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) December 2007 Copyright 2007 Lei Zhao |
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