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POSTMENOPAUSAL HORMONE THERAPY,
RISK OF HEART DISEASE AND TOTAL MORTALITY AMONG
WOMEN IN THE CALIFORNIA TEACHERS STUDY
by
Yuan Liu
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2007
Copyright 2007 Yuan Liu
Object Description
| Title | Postmenopausal hormone therapy, risk of heart disease and total mortality among women in the California Teachers Study |
| Author | Liu, Yuan |
| Author email | yuanliu@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2007-10-22 |
| Date submitted | 2007 |
| Restricted until | Restricted until 24 Oct. 2009. |
| Date published | 2009-10-24 |
| Advisor (committee chair) | Stram, Daniel |
| Advisor (committee member) |
Ursin, Giske Azen, Stanley |
| Abstract | Postmenopausal estrogen use has been strongly and consistently associated with reduced risk of coronary heart disease (CHD) in multiple observational studies. In contrast, clinical trials have shown no benefits and even suggested an increased risk of CHD. We aimed to clarify this relationship in our large cohort study -- the California Teachers Study (CTS).; Among 46,156 eligible women, 5,808 (12.6%) women died overall and 1,054 (2.3%) women died from heart attack by December 31, 2004. Risk of CHD death and total mortality was reduced in younger women with current hormone therapy. Compared with women who never used hormones, the relative risk of total mortality associated with current hormone therapy in women aged 55-59 was 0.61 (95% confidence interval=0.48-0.77). The preventive effect of hormone therapy on total mortality diminished as age increased with a significant trend (p<0.0001). Older hormone users and never users were at the same risk of all-cause death. |
| Keyword | hormone therapy; mortality; CHD |
| Geographic subject (state) | California |
| Geographic subject (country) | USA |
| Coverage date | circa 1995/2006 |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m884 |
| Rights | Liu, Yuan |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Liu-20071024 |
| Archival file | uscthesesreloadpub_Volume35/etd-Liu-20071024.pdf |
Description
| Title | Page 1 |
| Full text | POSTMENOPAUSAL HORMONE THERAPY, RISK OF HEART DISEASE AND TOTAL MORTALITY AMONG WOMEN IN THE CALIFORNIA TEACHERS STUDY by Yuan Liu A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) December 2007 Copyright 2007 Yuan Liu |
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