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ANALYSIS AND VISUALIZATION OF MULTI-MODE OPTICAL
SPECTRAL-SIGNATURE BIOIMAGING DATA FOR IN VIVO APPLICATIONS
by
Ji Hoon Jeong
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
December 2007
Copyright 2007 Ji Hoon Jeong
Object Description
| Title | Analysis and visualization of multi-mode optical spectral-signature bioimaging data for in vivo applications |
| Author | Jeong, Ji Hoon |
| Author email | jijeong@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2007-08-21 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-09-08 |
| Advisor (committee chair) |
Khoo, Michael C.K. Farkas, Daniel L. |
| Advisor (committee member) | Kast, W. Matin |
| Abstract | Biophotonics represents a major new area of hope and growth for high-tech medical and surgical intervention, and advanced optical imaging has much to offer and potentially a major role to play in this regard. In order to take advantage of recent advances in genomics, proteomics and cell biology in clinical practice, our level of understanding at tissue and pre-clinical levels needs to be enhanced using novel imaging-based technologies for quantification and visualization. In this dissertation, Multi-Mode Optical Spectral Signature (MMOSS) imaging for biomedical applications is introduced, and used to correlate histopathology with intra- and extraoperative imaging of normal and abnormal tissue specimens. Moreover, practical solutions to the challenges of applying MMOSS imaging technology to the real pre-clinical and clinical environment are proposed and implemented.; Among a number of optical imaging modes available to us, hyperspectral imaging and fluorescence lifetime imaging were more thoroughly tested in our animal models. All of the concepts and designs for multi-mode optical spectral signature were implemented and demonstrated using Java programming language, in our custom-developed software program SpectralJ. It is implemented as a plugin for ImageJ, an NIH supported opensource image processing suite, and it is equipped with many functional features such as spectral-signature management (signature selection, registration, load and search), spectral signature similarity measure algorithms, enhanced color representation methods, dimensionality reduction algorithms and intelligent signature imaging capabilities for efficient real-time in vivo imaging.; The usefulness of our new image analysis and visualization methods is demonstrated for selected preclinical research cases, including rat neck dissection, early detection of breast cancer, and the surgical management of Hirschprung's disease. |
| Keyword | multi-mode imaging; spectral signature imaging; hyperspectral imaging; fluorescence lifetime imaging |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m809 |
| Contributing entity | University of Southern California |
| Rights | Jeong, Ji Hoon |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Jeong-20070908 |
| Archival file | uscthesesreloadpub_Volume23/etd-Jeong-20070908.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | ANALYSIS AND VISUALIZATION OF MULTI-MODE OPTICAL SPECTRAL-SIGNATURE BIOIMAGING DATA FOR IN VIVO APPLICATIONS by Ji Hoon Jeong A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) December 2007 Copyright 2007 Ji Hoon Jeong |
