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INDUCTION POWER MICROBOLUS INFUSION PUMP USED FOR FUNCTIONAL NEUROIMAGING APPLICATIONS IN RODENTS
by
Tina Kahnamoee Givrad
_________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
August 2007
Copyright 2007 Tina Kahnamoee Givrad
Object Description
| Title | Induction power microbolus infusion pump for functional neuroimaging applications in rodents |
| Author | Givrad, Tina Kahnamoee |
| Author email | givrad@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2007-07-02 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-08-02 |
| Advisor (committee chair) | Maarek, Jean-Michel I. |
| Advisor (committee member) |
Holschneider, Daniel P. D'Argenio, David Z. [illegible] Meng, Ellis F. |
| Abstract | An implantable miniature infusion pump (MIP) that can be activated remotely has been designed for drug infusion in small animals. The MIP is composed of three main parts: (1) a reservoir, (2) an electronic module, and (3) an ejection chamber.; In the 1st generation of the MIP, the power supply consisted of four three-volt batteries in series. The design of the first generation of the MIP demonstrated its feasibility; however, a number of shortcomings prevented the widespread application and use of this technology in the scientific community. These problems include finite battery power, limited range for remote activation of the pump, sensitivity to ambient light, and the large size of the pressurized fluid reservoir.; The objective of my research was to design the second and third generations of the MIP in a way that solves the problems listed above. Wireless energy transfer is the transfer of electromagnetic energy from a primary coil to a secondary receiving coil without a physical connection. In the 2nd generation of the MIP, the battery was replaced by a radio-frequency power link to an external resonating inductive coil (primary coil) driven by a class E oscillator. With this design, significant power was transferred inductively to an implanted secondary coil that was small enough to be included as a power source for the MIP.; The design of the 3rd generation of the MIP added to the second generation a rechargeable battery in the receiver circuit, and a frequency-gated optical sensor that allowed activation of the pump at a distance using pulses of infrared light. In this design, the implanted rechargeable battery was charged in the animal's cage by inductive power transfer, and then operated independently from its power link in the freely moving animal. This design of MIP is suitable for open cage paradigms.; To reduce the size and weight of the implant, a new reservoir was designed. This 3-layer reservoir was built by molding silicone in two-part metal casts.; Another objective of this research was to design an implantable single-use miniature infusion pump to allow radiotracer injection and functional neuroimaging in mice. The pump was comprised of a pressurized reservoir, and an electrothermal valve, which opened to let tracer flow in the animal's circulation through an intravenous catheter. There is no commercially available reservoir or valve on the market, so there was a need to design these components in a way suitable for implantation in a 40-gram mouse. The pump was powered by inductive power transfer from an external 20 cm diameter primary coil to an implanted miniature, 1.5 cm diameter Litz-wire secondary coil capable of generating significant power at the frequency of 2 MHz. |
| Keyword | microbolus infusion pump; inductive power transfer |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m746 |
| Contributing entity | University of Southern California |
| Rights | Givrad, Tina Kahnamoee |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Givrad-20070802 |
| Archival file | uscthesesreloadpub_Volume35/etd-Givrad-20070802.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | INDUCTION POWER MICROBOLUS INFUSION PUMP USED FOR FUNCTIONAL NEUROIMAGING APPLICATIONS IN RODENTS by Tina Kahnamoee Givrad _________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) August 2007 Copyright 2007 Tina Kahnamoee Givrad |
