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LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
AND INSULIN SIGNAL TRANSDUCTION
by
Harshdeep Kaur
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(MOLECULAR AND EXPERIMENTAL PATHOLOGY)
August 2007
Copyright 2007
Harshdeep Kaur
Object Description
| Title | Low molecular weight protein tyrosine phosphatase and insulin signal transduction |
| Author | Kaur, Harshdeep |
| Author email | harshdek@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Pathobiology |
| School | Keck School of Medicine |
| Date defended/completed | 2007-06-05 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-08-07 |
| Advisor (committee chair) | Dubeau, Louis |
| Advisor (committee member) |
Bottini, Nunzio Widelitz, Randall B. Bottini, Nunzio |
| Abstract | The low molecular weight protein tyrosine phosphatase (LMPTP) is highly expressed in insulin-responsive tissues. LMPTP has been shown to play a role in glucose and lipid metabolism and its genetic polymorphism is associated with obesity and diabetes. Both in vitro and in vivo studies have been performed to demonstrate negative regulating effect of LMPTP on insulin signal transduction. In this study, my findings support the idea that LMPTP is a critical regulator of insulin signaling. LMPTP targets the activation segment of the insulin receptor and dephosphorylates it directly. Between the two isoforms of LMPTP, isoform 1 (IF1) seems to be catalytically more active than isoform 2 (IF2) on the insulin receptor. |
| Keyword | LMTPT |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m766 |
| Contributing entity | University of Southern California |
| Rights | Kaur, Harshdeep |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Kaur-20070807 |
| Archival file | uscthesesreloadpub_Volume14/etd-Kaur-20070807.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE AND INSULIN SIGNAL TRANSDUCTION by Harshdeep Kaur A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (MOLECULAR AND EXPERIMENTAL PATHOLOGY) August 2007 Copyright 2007 Harshdeep Kaur |
