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STUDY OF ISONIAZID-RESISTANT TUBERCULOSIS: MYCOBACTERIAL
GENOTYPIC CHARACTERIZATION AND CLINICAL FEATURES IN HUMAN
SUBJECTS
by
Patricio Escalante
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CLINICAL AND BIOMEDICAL INVESTIGATIONS)
August 2007
Copyright 2007 Patricio Escalante
Object Description
| Title | Study of isoniazid-resistant tuberculosis: mycobacterial genotypic characterization and clinical features in human subjects |
| Author | Escalante, Patricio |
| Author email | escalant@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Clinical & Biomedical Investigations |
| School | Keck School of Medicine |
| Date defended/completed | 2007-07-30 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-08-07 |
| Advisor (committee chair) | McKean-Cowdin, Roberta |
| Advisor (committee member) |
Azen, Stanley Larsen, Robert |
| Abstract | Most isoniazid-resistant (INHr) M. tuberculosis (MTB) isolates have katG mutations. KatG is a virulence factor in animal models. We aim to determine if MTB-INHr genotype is associated with distinct clinical features. A retrospective case-control study design was used to compare clinical characteristics of patients infected with INHr-MTB (katG or non-katG mutations) to patients with pan-sensitive (PS) MTB isolates. Univariate and multivariate analyses were used. Twenty-nine INHr-TB cases and 50 PS controls were evaluated. INHr-MTB patients infected with non-katG mutants were associated with a higher rate of sputum conversion at 1 month of treatment: Adjusted OR = 6.03 (95%CI: 1.02-35.4; P = 0.04). Patients infected with katG mutants were associated with a higher rate of unilateral lung disease: Adjusted OR = 10.7 (95%CI: 1.1-107; P = 0.04). Some MTB mutations resulting in INH resistance may be associated with a faster response to treatment, and others with a more contained pulmonary involvement. |
| Keyword | tuberculosis; isoniazid; virulence; katG; drug-resistance; clinical presentation |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m755 |
| Rights | Escalante, Patricio |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Escalante-20070807 |
| Archival file | uscthesesreloadpub_Volume44/etd-Escalante-20070807.pdf |
Description
| Title | Page 1 |
| Full text | STUDY OF ISONIAZID-RESISTANT TUBERCULOSIS: MYCOBACTERIAL GENOTYPIC CHARACTERIZATION AND CLINICAL FEATURES IN HUMAN SUBJECTS by Patricio Escalante A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CLINICAL AND BIOMEDICAL INVESTIGATIONS) August 2007 Copyright 2007 Patricio Escalante |
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