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ROLES OF THREE DOMAINS OF CCAR1 IN TRANSCRIPTION
ACTIVATION BY NUCLEAR RECEPTORS
by
In Kyoung Mah
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
May 2008
Copyright 2008 In Kyoung Mah
Object Description
| Title | Roles of three domains of CCAR1 in transcription activation by nuclear receptors |
| Author | Mah, In Kyoung |
| Author email | imah@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-03-26 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-04-21 |
| Advisor (committee chair) | Stallcup, Michael R. |
| Advisor (committee member) |
Tokes, Zoltan A. Stellwagen, Robert H. |
| Abstract | Nuclear receptors are ligand dependent transcription factors that activate target genes involved in diverse physiological processes such as metabolism, development, reproduction through the recruitment of multiple coactivators.; Cell cycle and apoptosis regulator 1 (CCAR1) is a nuclear receptor coactivator and helps to enhance the transcription activation by nuclear receptors. CCAR1 is also associated with the mediator complex, which recruits RNA polymerase II to the target gene promoters.; One of three domains of CCAR1 interacts with estrogen receptor. Deletions of three domains diminish the coactivator function of CCAR1. One domain is required for cooperation with CoCoA. In addition, three domains are required for collaboration with TRAP220 in estrogen receptor mediated transcription. One of three domains of CCAR1 is not necessary for the multiple coactivator complexes activity. Two domains of CCAR1 play important roles in TRAP220 associated GR dependent activity. Thus, three domains of CCAR1 might work differently in different conditions. |
| Keyword | nuclear receptor; coactivator |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1113 |
| Contributing entity | University of Southern California |
| Rights | Mah, In Kyoung |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-Mah-20080421 |
| Archival file | uscthesesreloadpub_Volume32/etd-Mah-20080421.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | ROLES OF THREE DOMAINS OF CCAR1 IN TRANSCRIPTION ACTIVATION BY NUCLEAR RECEPTORS by In Kyoung Mah A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) May 2008 Copyright 2008 In Kyoung Mah |
