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GENETIC VARIANTS AND SMOKING PROGRESSION IN CHINESE
ADOLESCENTS
by
Wei Sun
______________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PREVENTIVE MEDICINE)
August 2007
Copyright 2007 Wei Sun
Object Description
| Title | Genetic variants and smoking progression in Chinese adolescents |
| Author | Sun, Wei |
| Author email | wsun@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Preventive Medicine (Health Behavior) |
| School | Keck School of Medicine |
| Date defended/completed | 2007-04-27 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-06-18 |
| Advisor (committee chair) | Johnson, Andy |
| Advisor (committee member) |
Conti, David Unger, Jennifer Richardson, Jean Shih, Jean |
| Abstract | For adolescent smoking progression, understanding the potential risk factors, including genetic, psychosocial and other environmental factors, is important for identifying adolescents with high risk, and designing efficient prevention curriculum for deterring smoking development and nicotine dependence. The three studies of this dissertation, utilizing the sample from a longitudinal, randomized, school-based smoking prevention trial with 2661 urban 7th grade students at baseline, explore the patterns and risk factors for progressions of adolescent smoking and the potential moderating and mediating mechanisms among genetic and environmental risk factors.; Study 1 examined the association between genetic variants and smoking behavior, depression, and hostility/family conflict. Chinese male adolescents with the 3-repeat allele of MAOA smoked more numbers of cigarettes per day during last month than those with 4-repeat allele of MAOA (p=0.019). They had a smaller increase in cigarette use from baseline to one-year follow-up (p=0.013). We also found that the females with 3/3 repeat genotype of MAOA had larger increases in hostility scores than those with 4/4 repeat genotype in the two-year follow-up (p=0.026).; Study 2 investigated the potential risk and protective factors for smoking progression among adolescents. Regarding the smoking initiation, the boys with 3 repeats is 1.32 times more likely to become a life time ever smokers in the year-one follow-up. Regarding to the amount of cigarette use, for the boys with 4 repeats, those in the program group smoked significantly fewer than those in the control group (p=0.031). It suggests that a different set of risk/ protective factors exist for those adolescents with 3- or 4- repeat allele of MAOA.; Study 3 applied Latent growth curve analysis to investigate the mechanism of the influences of genetic and environmental factors on the smoking progression. In the model with allele size of MAOA as a risk factor and refusal self-efficacy as a mediator, the initial status or slope of refusal self-efficacy is significantly associated with initial status or slope of smoking progression for both boys and girls.; The results from these three studies suggest that repeat polymorphisms of MAOA is associated with the smoking progression among Chinese adolescent. |
| Keyword | genetic; random-effects model; smoking; adolescents; longitudinal |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m533 |
| Rights | Sun, Wei |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Sun-20070618 |
| Archival file | uscthesesreloadpub_Volume14/etd-Sun-20070618.pdf |
Description
| Title | Page 1 |
| Full text | GENETIC VARIANTS AND SMOKING PROGRESSION IN CHINESE ADOLESCENTS by Wei Sun ______________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PREVENTIVE MEDICINE) August 2007 Copyright 2007 Wei Sun |
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