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FLUID INTAKE, MICTURITION HABITS, ASSOCIATED MEDICATIONS AND
CONDITIONS AS POTENTIAL RISK FACTORS FOR BLADDER CANCER
by
Xuejuan Jiang
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(EPIDEMIOLOGY)
August 2007
Copyright 2007 Xuejuan Jiang
Object Description
| Title | Fluid intake, micturition habits, associated medications and conditions as potential risk factors for bladder cancer |
| Author | Jiang, Xuejuan |
| Author email | xuejuanj@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2007-06-14 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-06-27 |
| Advisor (committee chair) | Gago-Dominquez, Manuela |
| Advisor (committee member) |
Conti, David V. Groshen, Susan Cortessis, Victoria Kristence. Shibata, Darryl K. |
| Abstract | The urogenous-contact hypothesis proposes that the development of bladder cancer is associated with prolonged exposure to carcinogens in urine. To fully examine this hypothesis, this dissertation systematically addressed fluid intake, micturition habits, associated medical conditions, and medications in relation to risk of bladder cancer in the Los Angeles Bladder Cancer Case-Control Study.; Total fluid intake was not associated with risk of bladder cancer, but specific types of beverages had different influence on bladder cancer. Consumption of water and alcoholic beverages were associated with a reduced risk of bladder cancer, whereas consumption of coffee was associated with a slightly increased risk, especially among heavy drinkers. The alcohol-bladder cancer association was modified by genetic variations in glutathione S-transferases, and the coffee-bladder cancer association was modified by variations in N-acetyltransferase 2 and cytochrome P450 1A2.; This dissertation also examined the role of selected medical conditions and medications which have been shown to affect the intake of fluid and the frequency of urination. Women with a history of bladder infection had a lower risk of bladder cancer, while subjects with diabetes, heart attack, or gout exhibited a higher risk. A history of hypertension, and use of diuretics or antihypertensive drugs were not associated with bladder cancer; however, untreated hypertensive patients had a significantly reduction in bladder cancer risk compared to normotensive subjects, especially among men.; This dissertation also addressed the role of urination frequency on bladder carcinogenesis. The role of urination frequency was also addressed in this dissertation. Frequency of daytime urination seemed to exert its effect on bladder cancer depending on the substrate. The inverse associations between water intake, alcohol intake, and bladder cancer risk were modified by frequency of daytime urination with the reduction in risk confined to those who urinated more frequently. However, frequency of urination seemed not to play a role in the bladder infectionbladder cancer association. Nocturia was associated with an increased risk of bladder cancer among women. |
| Keyword | bladder cancer; fluid intake; alcohol; water; urinary tract infection |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m559 |
| Contributing entity | University of Southern California |
| Rights | Jiang, Xuejuan |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Jiang-20070627 |
| Archival file | uscthesesreloadpub_Volume26/etd-Jiang-20070627.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | FLUID INTAKE, MICTURITION HABITS, ASSOCIATED MEDICATIONS AND CONDITIONS AS POTENTIAL RISK FACTORS FOR BLADDER CANCER by Xuejuan Jiang A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (EPIDEMIOLOGY) August 2007 Copyright 2007 Xuejuan Jiang |
