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USE OF DNA METHYLATION INHIBITORS FOR CHEMOTHERAPY AND
CHEMOPREVENTION OF CANCER
by
Christine Bora Yoo
____________________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
August 2007
Copyright 2007 Christine Bora Yoo
Object Description
| Title | Use of DNA methylation inhibitors for chemotherapy and chemoprevention of cancer |
| Author | Yoo, Christine Bora |
| Author email | cyoo@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2007-04-27 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-06-07 |
| Advisor (committee chair) | Jones, Peter A. |
| Advisor (committee member) |
An, Woojin Debeau, Louis Laird-Offringa, Ite Shibata, Darryl |
| Abstract | Aberrant DNA methylation is a common feature of cancer, which has been targeted for pharmacologic intervention because of its reversible nature. Nucleoside analogs such as 5-azacytidine, 5-aza-2'-deoxycytidine, and zebularine are mechanism-based inhibitors of DNA methylation that are incorporated into the DNA during replication and deplete the DNA methyltransferase enzymes. 5-Azacytidine and 5-aza-2'-deoxycytidine are extremely potent inhibitors and may be ideal for use in chemotherapy of cancer. Delivery of these inhibitors has been facilitated with the use of short oligonucleotides that prevent enzymatic degradation. On the other hand, zebularine, a more stable and less toxic surrogate of the other two compounds may be best utilized as a chemopreventive agent. Chronic oral administration of zebularine in a murine colon cancer model highlighted its low toxicity and gender- and tissue-specific action against DNA methylation. |
| Keyword | epigenetics |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m517 |
| Rights | Yoo, Christine Bora |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Yoo-20070607 |
| Archival file | uscthesesreloadpub_Volume62/etd-Yoo-20070607.pdf |
Description
| Title | Page 1 |
| Full text | USE OF DNA METHYLATION INHIBITORS FOR CHEMOTHERAPY AND CHEMOPREVENTION OF CANCER by Christine Bora Yoo ____________________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOCHEMISTRY AND MOLECULAR BIOLOGY) August 2007 Copyright 2007 Christine Bora Yoo |
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