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NEUROPSYCHOLOGICAL FUNCTIONING IN OLDER ADULT
LONG-TERM CANCER SURVIVORS
by
Lara Heather Heflin
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PSYCHOLOGY)
December 2007
Copyright 2007 Lara Heather Heflin
Object Description
| Title | Neuropsychological functioning in older adult long-term cancer survivors |
| Author | Heflin, Lara Heather |
| Author email | lheflin@memory.ucsf.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Psychology |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2007-05-18 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-12-01 |
| Advisor (committee chair) | Meyerowitz, Beth |
| Advisor (committee member) |
Gatz, Margaret Mack, Wendy Schwartz, David Chambers, Kathleen |
| Abstract | Cancer and its treatment have been associated with a range of neuropsychological deficits, but the presence and temporal pattern of such problems in long-term cancer survivors are poorly understood. Moreover, although cognitive problems are likely to become most pronounced in older age, few studies have focused upon older cancer survivors or controlled for potential confounding variables. This research investigated cognitive functioning in older adult long-term cancer survivors in two studies. Using a co-twin control design, the first study found long-term cancer survival remained a significant risk for cognitive dysfunction, controlling for exercise, education, and depression. The first study also found long-term cancer survivors performed significantly worse than matched controls on verbal and visual recognition, but not on recall, verbal functioning, visuoconstruction, or information processing speed. The second study failed to replicate this pattern of deficits, finding no differences on any neuropsychological tests between long-term cancer survivors and a matched comparison group of individuals without a cancer history. However, individuals for whom pre- and post-cancer neuropsychological assessments were available showed significant declines on word list learning, compared to matched individuals without a cancer history. Implications of these findings are discussed. |
| Keyword | cancer; neuropsychological; older adult; cognitive; long-term |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m959 |
| Rights | Heflin, Lara Heather |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Heflin-20071201 |
| Archival file | uscthesesreloadpub_Volume40/etd-Heflin-20071201.pdf |
Description
| Title | Page 1 |
| Full text | NEUROPSYCHOLOGICAL FUNCTIONING IN OLDER ADULT LONG-TERM CANCER SURVIVORS by Lara Heather Heflin A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PSYCHOLOGY) December 2007 Copyright 2007 Lara Heather Heflin |
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