Page 1 |
Save page Remove page | Previous | 1 of 58 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
DISCOVERY OF NEW HIV-1 INTEGRASE INHIBITORS
by
Tino Wilson Sanchez
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(PHARMACEUTICAL SCIENCES)
May 2007
Copyright 2007 Tino Wilson Sanchez
Object Description
| Title | Discovery of new HIV-1 integrase inhibitors |
| Author | Sanchez, Tino Wilson |
| Author email | twsanche@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Pharmacy / Pharmaceutical Sciences |
| School | School of Pharmacy |
| Date defended/completed | 2007-03-07 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-04-24 |
| Advisor (committee chair) | Neamati, Nouri |
| Advisor (committee member) |
Haworth, Ian Wang, Clay |
| Abstract | We identified 49 novel HIV-1 IN inhibitors with a wide inhibitory profile. Furan and sulfonamide based inhibitors were tested in vitro against HIV-1 IN. Their inhibitory profiles were investigated to identify structural properties responsible for IN inhibition. In the presence of cofactor Mn2+, 22 compounds containing a central furan ring yielded six analogues showing IC50 < 10 µM. From 27 compounds containing a sulfonamide dithiazine moiety, eight analogues showed IC50 < 10 µM. Furan-based compound inhibition depends on a carboxylic acid moiety bound to a central furan ring. Compounds containing a salicylic acid group were most potent. Sulfonamide analogues show greatest inhibition with two aromatic moieties consisting of a secondary sulfonamide dithiazine ring and an acetophenone. Both furan and sulfonamide inhibitors are novel and are suitable for optimization. |
| Keyword | integrase; HIV |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m460 |
| Rights | Sanchez, Tino Wilson |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Sanchez-20070424 |
| Archival file | uscthesesreloadpub_Volume26/etd-Sanchez-20070424.pdf |
Description
| Title | Page 1 |
| Full text | DISCOVERY OF NEW HIV-1 INTEGRASE INHIBITORS by Tino Wilson Sanchez A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (PHARMACEUTICAL SCIENCES) May 2007 Copyright 2007 Tino Wilson Sanchez |
Comments
Post a Comment for Page 1
