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ROLE OF FGFR2B SIGNALING PATHWAY IN THE DEVELOPMENT OF
ECTODERMAL DERIVATIVES
by
Sara Parsa
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PATHOBIOLOGY)
December 2010
Copyright 2010 Sara Parsa
Object Description
| Title | Role of FGFR2b signaling pathway in the development of ectodermal derivatives |
| Author | Parsa, Sara |
| Author email | memolus@yahoo.com; sarapars@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Pathobiology |
| School | Keck School of Medicine |
| Date defended/completed | 2010-05-05 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-12-14 |
| Advisor (committee chair) | Bellusci, Saverio |
| Advisor (committee member) |
Warburton, David Widelitz, Randall Hofman, Florence Dubeau, Louis |
| Abstract | The Fibroblast growth factor (FGF) family consists of 23 members, which play important roles during development, homeostasis and pathogenesis by controlling proliferation, migration and differentiation of cells in multiple organs. Among FGFs, we are interested in the role of FGF10 and its receptor, FGFR2b in development of ectodermal derivatives such as mammary gland, limbs and incisors. In this study we mainly used rtTA transactivator/tetracycline promoter approach allowing inducible and reversible attenuation of the FGFR2b pathway throughout the embryonic and adult mouse upon addition of doxycycline. Our study in mammary gland demonstrates the importance of FGFR2b signaling pathway for maintenance of the terminal end buds (TEBs) at the tip of the adult mammary gland. TEBs consist of transit amplifying cells (TACs), which are developed from adult mammary stem cells. We also report that while FGFR2b signaling is not crucial for the regenerative potential of the mammary epithelial stem cells, it has a critical role in the regulation of luminal epithelial lineage commitment of mammary stem cells in the adult mouse. In the second study, it is shown that FGFR2b signaling is critical for the regenerative capacity of adult incisors by controlling the proliferation of ameloblast progenitor cells. In the last study, we show that Apical Ectodermal Ridge (AER), the key structure for limb bud formation, requires FGFR2b signaling to maintain its structure. At last, in the following dissertation we discuss the crucial role of FGFR2b signaling pathway in controlling the behavior of stem/progenitor cells of different ectodermal-derived organs in both embryonic and adult mouse. |
| Keyword | FGF signaling; FGF10; FGFr2b; apical ectodermal ridge; limb; incisor; cervical loop; mammary gland; bipotent progenitor cells; luminal progenitor cells; terminal end buds |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3595 |
| Contributing entity | University of Southern California |
| Rights | Parsa, Sara |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Parsa-3818 |
| Archival file | uscthesesreloadpub_Volume14/etd-Parsa-3818.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Full text | ROLE OF FGFR2B SIGNALING PATHWAY IN THE DEVELOPMENT OF ECTODERMAL DERIVATIVES by Sara Parsa A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PATHOBIOLOGY) December 2010 Copyright 2010 Sara Parsa |
