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EFFECT OF SOY ISOFLAVONES ON ANTHROPOMETRIC AND
METABOLIC MEASUREMENTS IN POSTMENOPAUSAL WOMEN
by
Jun Wang
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(APPLIED BIOSTATISTICS AND EPIDEMIOLOGY)
May 2011
Copyright 2011 Jun Wang
Object Description
| Title | Effect of soy isoflavones on anthropometric and metabolic measurements in postmenopausal women |
| Author | Wang, Jun |
| Author email | wangjun@usc.edu; jwang1206@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Applied Biostatistics & Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2010-12-12 |
| Date submitted | 2011 |
| Restricted until | Unrestricted |
| Date published | 2011-01-24 |
| Advisor (committee chair) | Mack, Wendy |
| Advisor (committee member) |
Azen, Stanley P. Hodis, Howard N. |
| Abstract | In this single-center, randomized, double-blinded, placebo-controlled clinical trial, 350 postmenopausal women were randomized to either soy isoflavone or placebo groups and followed for 2.5 years. The soy isoflavone group received 25g soy protein containing 85mg soy isoflavones daily, and the placebo group received matched placebo. Generalized estimating equations with identity link function and exchangeable correlation structure were conducted to examine the treatment effects on anthropometric and metabolic parameters in total subjects or among subgroups defined by equol producer, time since menopause, age and ethnicity. The association between plasma isoflavone levels and changes in anthropometric and metabolic parameters were also examined.; The soy isoflavone group did not differ from the placebo group in mean change of LDL-cholesterol, glucose, total cholesterol, or anthropometric measurements. Compared to placebo, the mean increase of HDL-cholesterol was marginally higher in the soy isoflavones group (p=0.05), the difference was significant in white women and those who experienced menopause less than 5 years ago (both p=0.04). The mean increase of triglycerides was marginally lower (p=0.05) in the ISP group compared to placebo (p=0.05), the difference was significant in white women (p=0.03) and women aged 56 to 60 years old (p=0.01). The mean change of triglycerides in the non-equol producer and the consistent equol producer subgroups were significantly lower than the placebo group (both p=0.04). Plasma dihydrogenistein was negatively associated with hip circumference (β=-0.56; p=0.01) but positively associated with waist circumference (β=0.53; p=0.02). Plasma genistein level was also negatively associated with hip circumference (β=-0.16; p=0.01).; This analysis indicates that daily consumption of 25g soy protein containing 85mg isoflavones has no overall effect on anthropometric measurements but has potentially beneficial effects on lipids in postmenopausal women. However, plasma isoflavone levels are associated with hip and waist circumference. Equol-producing capability modifies the effect of isoflavones on triglycerides. |
| Keyword | soy; isoflavones; anthropometric; metabolic; postmenopausal women; lipid; clinical trials |
| Geographic subject (country) | USA |
| Coverage date | 2004/2007 |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3621 |
| Rights | Wang, Jun |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Wang-4238 |
| Archival file | uscthesesreloadpub_Volume26/etd-Wang-4238.pdf |
Description
| Title | Page 1 |
| Full text | EFFECT OF SOY ISOFLAVONES ON ANTHROPOMETRIC AND METABOLIC MEASUREMENTS IN POSTMENOPAUSAL WOMEN by Jun Wang A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATISTICS AND EPIDEMIOLOGY) May 2011 Copyright 2011 Jun Wang |
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