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INTERLEUKIN-11: A STUDY OF ITS EFFECTS IN GLIOBLASTOMA MULTIFORME
by
Zhi Liu
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
December 2010
Copyright 2010 Zhi Liu
Object Description
| Title | Interleukin-11: a study of its effects in glioblastoma multiforme |
| Author | Liu, Zhi |
| Author email | zhiliu@usc.edu; zhiliu.usc@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-11-22 |
| Advisor (committee chair) | Tokes, Zoltan A. |
| Advisor (committee member) |
Hofman, Florence M. DeClerck, Yves A. |
| Abstract | Interleukin-11 (IL-11) is a member of the interleukin-6 (IL-6) cytokine family, which utilizes a common membrane glycoprotein 130 (gp130) for signal transduction. Previously it had been shown IL-11 was an anti-inflammatory cytokine, stimulated megakaryocyte diffentiation and was used for treatment of chemotherapy-induced thrombocytopenia. Recently more attentions have been paid to its function in cancer. There is growing evidence showing IL-11 plays a role in tumor progression in many types of cancer. In our investigation, we studied the expression of IL-11 and its function on tumor angiogenesis and tumor progression, using glioblastoma multiforme (GBM), the most malignant, highly vascular and invasive brain tumor. Our studies show that IL-11 is present abundantly in the GBM tumor tissue as compared to the normal brain, and IL-11 has multiple effects. First, IL-11 stimulates normal and tumor-associated brain endothelial cells to migrate, and has no effect on cell proliferation. This suggests that IL-11 may play a role in promoting angiogenesis as a pro-angiogenic factor. Second, it enhances glioma cell migration and invasion without affecting cell number, indicating that IL-11 may be involved in glioma tumor invasion and progression. In addition, IL-11 receptor alpha, the binding receptor of IL-11, is expressed by tumor cells in GBM tissues while not expressed by astrocytes in the normal brain specimens. In summary, our studies suggest novel functions of IL-11 in GBM tumor. These findings are of great importance since they provide meaningful evidence for us to understand GBM better and potentially provide new therapeutic target for the treatment of this fatal disease. |
| Keyword | angiogenesis; brain endothelial cells; glioblastoma multiforme; interleukin-11; invasion; migration |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3551 |
| Rights | Liu, Zhi |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Liu-4192 |
| Archival file | uscthesesreloadpub_Volume40/etd-Liu-4192.pdf |
Description
| Title | Page 1 |
| Full text | INTERLEUKIN-11: A STUDY OF ITS EFFECTS IN GLIOBLASTOMA MULTIFORME by Zhi Liu A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) December 2010 Copyright 2010 Zhi Liu |
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