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PERSONAL HAIR DYE USE AND RISK OF B-CELL NON-HODGKIN’S LYMPHOMAS AMONG ADULT WOMEN IN LOS ANGELES COUNTY
by
Xinxin Xu
———————————————————————————
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(APPLIED BIOSTATISTICS AND EPIDEMIOLOGY)
December 2010
Copyright 2010 Xinxin Xu
Object Description
| Title | Personal hair dye use and risk of B-cell non-Hodgkin’s lymphomas among adult women in Los Angeles County |
| Author | Xu, Xinxin |
| Author email | xinxinxu@usc.edu; reranxin@hotmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Applied Biostatistics & Epidemiology |
| School | Keck School of Medicine |
| Date submitted | 2010 |
| Restricted until | Restricted until 16 May. 2011. |
| Date published | 2011-05-16 |
| Advisor (committee chair) | Bernstein, Leslie |
| Advisor (committee member) |
Mack, Wendy Azen, Stanley |
| Abstract | Study Aim: There have been inconsistent reports regarding personal hair dye use and B-cell non-Hodgkin’s lymphomas (NHL) risk. This study aims to evaluate the relationship between women’s personal hair dye use and the risk of B-cell NHL. Methods: A 1:1 matched population-based case-control study of women conducted in Los Angeles County recruited 986 case-control pairs. Case participants were diagnosed with histologic confirmed primary B-cell NHL between 2004 and 2008. Control participants were individually matched to the index cases by age, gender, race, and neighborhood of residence. Exposure information was obtained by in-person interviews. Multivariable conditional logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of B-cell NHL associated with personal hair dye use overall, by race, and by NHL subtypes, adjusting for potential confounders (alcohol status, smoking status, and education levels).; Results: Compared to women who had never used any hair dye products, those who had ever used personal hair dyes had a 38% greater risk for B-cell NHL (OR=1.38, 95%CI=1.05-1.31). A younger age at first hair dye use, a longer duration of hair dye use, and a greater number of hair dye applications were all associated with an elevated risk of B-cell NHL (p-values for trend=0.007, 0.006, 0.025, respectively). Relative risk estimates were higher for those who had ever used permanent dyes (OR=1.46, 95%CI=1.11-1.93), black hair dyes (OR=1.76, 95%CI=1.18-2.63), and also higher for those who initiated hair dye use prior to 1980 (OR=1.45, 95%CI=1.08-1.96). The influence patterns were similar across different racial/ethnic groups. Increased risk of follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) were observed in this study.; Conclusion: The results from this study support the hypothesis that hair dye use, and particularly using permanent hair dyes, using black hair dyes, and year of initiation of use prior to 1980 increase the risk of B-cell NHL, especially the follicular lymphoma and CLL/SLL subtypes. Further research is warranted to address the effects of specific types, colors, or components of hair dye products, as well as the underlying biological mechanisms which mediate the increase in B-cell NHL risk. |
| Keyword | case-control study; hair dyes; non-Hodgkin's lymphoma; risk factors; women |
| Geographic subject (county) | Los Angeles |
| Geographic subject (state) | California |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3531 |
| Rights | Xu, Xinxin |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Xu-4189 |
| Archival file | uscthesesreloadpub_Volume29/etd-Xu-4189.pdf |
Description
| Title | Page 1 |
| Full text | PERSONAL HAIR DYE USE AND RISK OF B-CELL NON-HODGKIN’S LYMPHOMAS AMONG ADULT WOMEN IN LOS ANGELES COUNTY by Xinxin Xu ——————————————————————————— A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATISTICS AND EPIDEMIOLOGY) December 2010 Copyright 2010 Xinxin Xu |
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