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CONTROL STRATEGIES FOR THE
REGULATION OF BLOOD GLUCOSE
by
Michail G. Markakis
A Thesis Presented to the
FACULTY OF THE USC VITERBI SCHOOL OF ENGINEERING
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(ELECTRICAL ENGINEERING)
May 2008
Copyright 2008 Michail G. Markakis
Object Description
| Title | Control strategies for the regulation of blood glucose |
| Author | Markakis, Michail G. |
| Author email | markakis@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Electrical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2008-02-27 |
| Date submitted | 2008 |
| Restricted until | Restricted until 27 Mar. 2010. |
| Date published | 2010-03-27 |
| Advisor (committee chair) | Marmarelis, Vasilis |
| Advisor (committee member) |
Safonov, Michael Ordonez, Fernando |
| Abstract | In this computational study, we develop two nonlinear control algorithms (termed the Hybrid Control Strategy and the Switching Control Strategy ) and evaluate their performance relative to the widely studied Proportional-Derivative Controller for the regulation of blood glucose with intravenous insulin infusions in diabetic patients. For the requisite simulations of the causal relationship between infused insulin and blood glucose we introduce a new model (termed the Augmented Minimal Model ) and a glucose rate disturbance signal that represents the aggregate effects of the various neuro-hormonal, behavioral and metabolic factors affecting blood glucose. The obtained results show that the Switching Control Strategy can regulate blood glucose better than the other two controllers (based on widely accepted metrics of performance), while eliminating the risk of inadvertent hypoglycaemia and remaining remarkably robust in the event of unknown variations in critical parameters of the model. However, the other two controllers exhibit a satisfactory performance too. |
| Keyword | diabetes; intravenous insulin; blood glucose; PID control; model predictive control |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1060 |
| Rights | Markakis, Michail G. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Markakis-20080327 |
| Archival file | uscthesesreloadpub_Volume26/etd-Markakis-20080327.pdf |
Description
| Title | Page 1 |
| Full text | CONTROL STRATEGIES FOR THE REGULATION OF BLOOD GLUCOSE by Michail G. Markakis A Thesis Presented to the FACULTY OF THE USC VITERBI SCHOOL OF ENGINEERING UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (ELECTRICAL ENGINEERING) May 2008 Copyright 2008 Michail G. Markakis |
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