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Inhibition of sexual behavior in naïve male rats by infusion of vasopressin or V1b
vasopressin receptor antagonist into the olfactory bulb
by
Nicholas N. Foster
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF ARTS
(PSYCHOLOGY)
December 2006
Copyright 2006 Nicholas N. Foster
Object Description
| Title | Inhibition of sexual behavior in naive male rats by infusion of vasopressin or V1b vasopressin receptor antagonist into the olfactory bulb |
| Author | Foster, Nicholas N. |
| Author email | nfoster@usc.edu |
| Degree | Master of Arts |
| Document type | Thesis |
| Degree program | Psychology |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2006-10-01 |
| Date submitted | 2006 |
| Restricted until | Unrestricted |
| Date published | 2006-11-27 |
| Advisor (committee chair) | Chambers, Kathleen C. |
| Advisor (committee member) |
Mitchell, Denis Gatz, Margaret |
| Abstract | Arginine vasopressin (AVP) is a neuropeptide known to influence many rodent social behaviors. Experiment 1 assessed the effects on sexual behavior of AVP (1 ng) infusions into the olfactory bulbs of male rats, finding that AVP significantly inhibited the number of intromissions displayed compared to control animals. Experiment 2 sought to expand upon these findings by comparing groups receiving injections of AVP, a V1b vasopressin receptor antagonist, both AVP and the antagonist (1 ng in all cases), or vehicle. Additionally, immediately after testing, brain tissue samples were collected and were assayed for c-Fos expression in the medial amygdala. AVP alone and paired with the antagonist caused significant reductions in intromission. All drug-treated groups expressed significantly less c-Fos than controls. A model of olfactory processing is proposed whereby the antagonist depresses the function of mitral cells, the primary olfactory bulb efferents, while AVP activates granule cells, which inhibit mitral cells. |
| Keyword | social behavior; olfaction; c-Fos; medial amygdala |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m193 |
| Contributing entity | University of Southern California |
| Rights | Foster, Nicholas N. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-Foster-20061127 |
| Archival file | uscthesesreloadpub_Volume29/etd-Foster-20061127.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | Inhibition of sexual behavior in naïve male rats by infusion of vasopressin or V1b vasopressin receptor antagonist into the olfactory bulb by Nicholas N. Foster A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF ARTS (PSYCHOLOGY) December 2006 Copyright 2006 Nicholas N. Foster |
