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BILATERAL TESTICULAR GERM CELL TUMORS: DISTRIBUTION OF
HISTOLOGIC TYPES
by
Jennifer Phay Thomas
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(APPLIED BIOSTATISTICS AND EPIDEMIOLOGY)
August 2010
Copyright 2010 Jennifer Phay Thomas
Object Description
| Title | Bilateral testicular germ cell tumors: distribution of histologic types |
| Author | Thomas, Jennifer Phay |
| Author email | jennifer.thomas@med.usc.edu; jennphay@hotmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2010-07-01 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-08-09 |
| Advisor (committee chair) | Cortessis, Victoria K. |
| Advisor (committee member) |
Siegmund, Kimberly Hamilton, Ann |
| Abstract | Testicular germ cell tumors (TGCT) are the most commonly diagnosed neoplasm of young men 15-45 years of age, and incidence of these tumors has been increasing in recent decades for reasons currently unknown. Histologic type of TGCT can be divided into the broad categories of seminomas and non-seminomas. It currently remains to be elucidated if these histologic types share a common etiology. In this study we analyzed the largest set of bilateral cases of TGCT ever assembled, 550, to determine if the histologic type of the first tumor predicts that of the second. Presuming an individual with a history of two primary tumors has the same risk factors for both tumors, a concordance of histologic types in the same individual would suggest that the risk factors for seminomas and non-seminomas differ. The data show no association between the histologic type of the first and second tumors when the analysis is adjusted for the age at first diagnosis (odds ratio (OR)=0.95) This finding suggests that the two broad histologic types share a common etiology, but some age related factor impacts differentiation between the two. We also compared 16,204 presumed unilateral cases of TGCT to 440 bilateral cases matched on year of birth and region of diagnosis to determine if histologic type of the first/only TGCT confers risk of developing a second TCGT. This analysis suggests that a first diagnosis of seminoma is a risk factor for developing testicular cancer after adjustment for age at first or only diagnosis (OR=1.401; 95% CI=1.135-1.730). This finding suggests that seminomatous first tumors should be considered as a risk factor for the development of bilateral TCGT despite the current view that non-seminomatous TGCT are considered to be more aggressive. |
| Keyword | testis; cancer; epidemiology; histologic types; bilateral |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3352 |
| Rights | Thomas, Jennifer Phay |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Thomas-3484 |
| Archival file | uscthesesreloadpub_Volume51/etd-Thomas-3484.pdf |
Description
| Title | Page 1 |
| Full text | BILATERAL TESTICULAR GERM CELL TUMORS: DISTRIBUTION OF HISTOLOGIC TYPES by Jennifer Phay Thomas A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATISTICS AND EPIDEMIOLOGY) August 2010 Copyright 2010 Jennifer Phay Thomas |
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