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FDG PET-CT IN METASTATIC PROSTATE CANCER
by
Bhushan Desai
_______________________________________________________________________
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements of the Degree
MASTER OF SCIENCE
(CLINICAL AND BIOMEDICAL INVESTIGATIONS)
August 2010
Copyright 2010 Bhushan Desai
Object Description
| Title | FDG PET-CT in metastatic prostate cancer |
| Author | Desai, Bhushan B. |
| Author email | bhushand@usc.edu; dr.bhushandesai@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Clinical & Biomedical Investigations |
| School | Keck School of Medicine |
| Date defended/completed | 2010-06-30 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-08-06 |
| Advisor (committee chair) | Jadvar, Hossein |
| Advisor (committee member) |
Pinski, Jacek Groshen, Susan |
| Abstract | The aims of present thesis are:1)To provide a pictorial view of the various sites of metastasis from prostate cancer as detected by FDG PET-CT scan and to compare its diagnostic potential with the conventional gold standard imaging modalities (CT and Tc 99m-MDP bone scintigraphy).2)To assess the diagnostic utility of 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) compared to Computed Tomography (CT) in detection of lymph node metastasis in men with metastatic prostate cancer.3)To compare the diagnostic utility of FDG-PET, CT and Bone scans in evaluation of osseous metastasis in men with malignant prostate cancer.4)To determine the effects of clinical variables (PSA, calcium, Gleason score, Alkaline Phosphatase) in predicting a bone vs. non-bone (LN+ soft tissue) dominant disease on FDG PET/CT in men with metastatic prostate cancer.5)To identify interesting cases depicting the role of 18F-FDG PET scan for evaluation of response to treatment in metastatic prostate cancer.-Castrate-sensitive patients-Castrate- resistant patients; Our long-range objective is to investigate the ability of the new hybrid positron emission tomography and computed tomography (PET-CT) imaging systems to assess treatment response in patients with metastatic prostate cancer in comparison to conventional imaging. We believe that the combined anatomic and in-vivo metabolic imaging information provided by PET-CT allows accurate objective assessment of such critical clinical issues as early prediction and evaluation of response or resistance to various therapeutic interventions, involving the novel chemotherapy regimen, as well as the prediction of key clinical outcomes such as time to hormone-refractoriness and survival. |
| Keyword | FDG; PET-CT; prostate cancer; PSA; castrate-sensitive; castrate-resistant |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3319 |
| Rights | Desai, Bhushan B. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Desai-3912 |
| Archival file | uscthesesreloadpub_Volume29/etd-Desai-3912.pdf |
Description
| Title | Page 1 |
| Full text | FDG PET-CT IN METASTATIC PROSTATE CANCER by Bhushan Desai _______________________________________________________________________ A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements of the Degree MASTER OF SCIENCE (CLINICAL AND BIOMEDICAL INVESTIGATIONS) August 2010 Copyright 2010 Bhushan Desai |
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