Page 1 |
Save page Remove page | Previous | 1 of 185 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
MEMORY ABNORMALITIES IN ALZHEIMER‟S DISEASE AND ANXIETY MODELS
by
Chanpreet Singh
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(NEUROSCIENCE)
May 2010
Copyright 2010 Chanpreet Singh
Object Description
| Title | Memory abnormalities in Alzheimer's disease and anxiety models |
| Author | Singh, Chanpreet |
| Author email | csingh@usc.edu; nbali@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Neuroscience |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2010-03-22 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-05-07 |
| Advisor (committee chair) | Thompson, Richard F. |
| Advisor (committee member) |
Brinton, Roberta D. Baudry Michel Swanson Larry Madigan Stephen A. |
| Abstract | This dissertation seeks to investigate the memory abnormalities that result from Alzheimer's disease and anxiety disorders. In particular, this dissertation will focus on investigating if neurogenic deficits in the hippocampus contribute to the etiology of Alzheimer's disease by studying a hippocampal-dependent associative behavior test. Additionally, we will study the potential of allopregnanolone (APα), a metabolite of progesterone, to increase neurogenesis in the hippocampus of mice and to determine the functional significance of these new neurons. Our data has demonstrated that APα reverses the neurogenic and cognitive deficits of Alzheimer's disease mice to levels of age-matched normal mice. This study suggests that APα could serve as a regenerative therapeutic to prevent or delay neurogenic and cognitive deficits associated with mild cognitive impairment and Alzheimer's disease. As a second part of this thesis, we have investigated memory abnormalities in a mouse model of anxiety. This mouse model does not have any monoamine oxidase A and B and hence, has significantly elevated levels of monoaminergic neurotransmitters. Previous study has shown that MAO A/B KO mice have anxiety-like behavior. As a further characterization of these mice, we have found that there is a significant enhancement of emotional memories in these mutants and point to these mice as an interesting animal model to study the role of monoamines in fear-related behaviors and post-traumatic stress disorder. Furthermore, MAO A/B KO mice have shown enhanced level of learning in cerebellar-dependent delay eyeblink conditioning, further shedding light on the possible role of monoaminergic afferents in the modulation of motor learning in the cerebellum. |
| Keyword | allopregnanolone; Alzheimer's disease; anxiety; eyeblink conditioning; learning and memory; neurogenesis |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3038 |
| Rights | Singh, Chanpreet |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Singh-3612 |
| Archival file | uscthesesreloadpub_Volume17/etd-Singh-3612.pdf |
Description
| Title | Page 1 |
| Full text | MEMORY ABNORMALITIES IN ALZHEIMER‟S DISEASE AND ANXIETY MODELS by Chanpreet Singh A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (NEUROSCIENCE) May 2010 Copyright 2010 Chanpreet Singh |
Comments
Post a Comment for Page 1
