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Regulation of long chain fatty acid metabolism in skeletal muscle: effects of insulin and exercise induced signaling pathways

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Title	Regulation of long chain fatty acid metabolism in skeletal muscle: effects of insulin and exercise induced signaling pathways
Author	Kelly, Karen Rachele
Author email	karenkelly012@hotmail.com
Degree	Doctor of Philosophy
Document type	Dissertation
Degree program	Kinesiology
School	College of Letters, Arts and Sciences
Date defended/completed	2007-02-07
Restricted until	Unrestricted
Advisor (committee chair)	Turcotte, Lorraine
Advisor (committee member)	Donovan, Casey Youn, Jang
Abstract	The purpose of the current investigation was to determine whether; (1) Insulin, independently of glucose regulates LCFA metabolism and if so to determine the signaling pathway by which it has its effects, (2) Chronic AMPK activation enhances insulin-sensitive fatty acid metabolism, and (3) Increasing intracellular calcium effects LCFA metabolism. Three experimental series were conducted using L6 myotubes and provide novel information on the regulation of LCFA in muscle.
Keyword	fatty acid metabolism; insulin signaling; exercise signaling
Language	English
Part of collection	University of Southern California dissertations and theses
Publisher (of the original version)	University of Southern California
Place of publication (of the original version)	Los Angeles, California
Publisher (of the digital version)	University of Southern California. Libraries
Type	texts
Legacy record ID	usctheses-m307
Rights	Kelly, Karen Rachele
Repository name	Libraries, University of Southern California
Repository address	Los Angeles, California
Repository email	http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/
Filename	etd-Kelly-20070302
Archival file	uscthesesreloadpub_Volume23/etd-Kelly-20070302.pdf

Title	Page 1
Full text	REGULATION OF LONG CHAIN FATTY ACID METABOLISM IN SKELETAL MUSCLE: EFFECTS OF INSULIN AND EXERCISE INDUCED SIGNALING PATHWAYS by Karen Rachele Kelly A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (KINESIOLOGY) May 2007 Copyright 2007 Karen Rachele Kelly

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Regulation of long chain fatty acid metabolism in skeletal muscle: effects of insulin and exercise induced signaling pathways

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