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SURFACE MODIFICATION OF PARYLENE C AND INDIUM TIN OXIDE FOR
RETINAL AND CORTICAL PROSTHESES
by
Paulin Nadi Wahjudi
________________________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(CHEMISTRY)
May 2007
Copyright 2007 Paulin Nadi Wahjudi
Object Description
| Title | Surface modification of parylene C and indium tin oxide for retinal and cortical prostheses |
| Author | Wahjudi, Paulin Nadi |
| Author email | wahjudi@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Chemistry |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2007-03-19 |
| Date submitted | 2007 |
| Restricted until | Restricted until 31 May 2010. |
| Date published | 2010-05-31 |
| Advisor (committee chair) | Thompson, Mark E. |
| Advisor (committee member) |
Reisler, Hanna Shing, Katherine Bau, Robert Weber, William |
| Abstract | In the world of prosthesis, the interaction between the material and the tissue is as essential as the efficiency of the device itself. Development in medical devices to improve health and health care would be immensely benefited by the ability to tailor the interface of tissue and material according to the specific needs of each device. In this thesis, works on surface modification of parylene C film and indium tin oxide (ITO) for retinal and cortical prosthesis are presented. As the works combine the multidisciplinary fields of chemistry, material science, and biology, chapter one is targeted to provide general background of the retinal and prosthesis, and the tissue-material interface that are required for the two prostheses. The second chapter will discuss how selective chemical surface modifications of parylene C thin film were carried out to introduce various functional groups and grafting of poly-N-isopropylacrylamide onto the parylene surface via atom transfer radical polymerization. The improvement of gold metal electrode and tissue adhesion onto the modified thin film will also be discussed in this chapter. Works on ITO surface will be describe in chapter three, including the selective surface modification of ITO, methods to functionalized ITO surface with cell adhesion molecules (CAMs), and the neuron cell culture results. Lastly, the appendix will discussed previous work on direct production of hydrogen peroxide utilizing viologen-palladium embedded in inert scaffold. |
| Keyword | surface modification; parylene C; indium tin oxide; retinal prosthesis; cortical prosthesis |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m362 |
| Rights | Wahjudi, Paulin Nadi |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Wahjudi-20070410 |
| Archival file | uscthesesreloadpub_Volume32/etd-Wahjudi-20070410.pdf |
Description
| Title | Page 1 |
| Full text | SURFACE MODIFICATION OF PARYLENE C AND INDIUM TIN OXIDE FOR RETINAL AND CORTICAL PROSTHESES by Paulin Nadi Wahjudi ________________________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (CHEMISTRY) May 2007 Copyright 2007 Paulin Nadi Wahjudi |
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