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A COMPUTER-AIDED-DIAGNOSIS (CAD) METHOD COMBINING
PHALANGEAL AND CARPAL BONE FEATURES FOR BONE AGE ASSESSMENT
OF CHILDREN
by
Aifeng Zhang
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
May 2007
Copyright 2007 Aifeng Zhang
Object Description
| Title | A computer-aided diagnosis (CAD) method combining phalangeal and carpal bone features for bone age assessment of children |
| Author | Zhang, Aifeng |
| Author email | azhang@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2007-02-28 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-04-09 |
| Advisor (committee chair) | Huang, Han K. |
| Advisor (committee member) |
Liu, Brent J. Siegel, Martin McNulty, James V. |
| Abstract | Bone age assessment (BAA) is a clinical procedure performed in pediatric radiology to quickly and non-invasively evaluate the stage of skeletal maturation based on a left hand and wrist radiograph of the subject. Two disadvantages in the commonly used Greulich and Pyle (G&P) atlas method -- outdated data collection and inter- and intra-observer discrepancies -- created a need for a new data collection and an objective, automatic BAA method. A computer-aided-diagnosis (CAD) system based on phalangeal region of interest (ROI) was previously developed, however it was insufficient for BAA of young children. This research proposed to augment the feature space with carpal ROI to ensure the BAA accuracy for children from 0-18.; A total of 1,400 hand images were recently acquired from Children's Hospital Los Angeles for four major populations in the U.S., including Asian, African American, Caucasian and Hispanic. The normality and consistency of the data collection was ensured with a sophisticated quality assurance protocol and radiologists' readings. This database provided an up-to-date normal growth and development standard.; This dissertation established a novel CAD development scheme with continuous non-discreet output for BAA. It demonstrated the applicability of anisotropic diffusion filtration and Canny edge detection in segmenting the carpal bones from the hand images. A knowledge-based model was able to identify each carpal bone from the segmented objects. In addition, correlating carpal bone to maturity stages by analyzing morphological features further advanced understanding of skeletal development. The bone age was assessed by a fuzzy logic system based on the carpal bone features. The statistical evaluation demonstrated the contribution of carpal bones in providing reliable growth information for young children under 7 years of age. Furthermore, a modular and extensible fuzzy integration system combined information from phalangeal and carpal regions.; The applicability of G&P atlas to today's children was challenged by significant discrepancies observed in Asian and Hispanic populations compared to African American and Caucasian in this research. Trained to adapt to different populations around the world, the CAD system integrated in PACS (Picture Archiving and Communication System) becomes a clinical tool in assisting radiologists to achieve higher accuracy and effectiveness of BAA. |
| Keyword | bone age assessment; computer-aided-diagnosis; carpal bone; phalangeal; image processing |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m359 |
| Rights | Zhang, Aifeng |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Zhang-20070409 |
| Archival file | uscthesesreloadpub_Volume32/etd-Zhang-20070409.pdf |
Description
| Title | Page 1 |
| Full text | A COMPUTER-AIDED-DIAGNOSIS (CAD) METHOD COMBINING PHALANGEAL AND CARPAL BONE FEATURES FOR BONE AGE ASSESSMENT OF CHILDREN by Aifeng Zhang A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) May 2007 Copyright 2007 Aifeng Zhang |
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