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LOCALIZATION OF ENDOGENOUS NEUROTROPHINS IN TWO
CORTICAL REGIONS AND THEIR ROLE IN NEURON SURVIVAL DURING
VOCAL LEARNING IN ZEBRA FINCH
by
Allison Quaglino
_____________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(NEUROSCIENCE)
May 2007
Copyright 2007 Allison Quaglino
Object Description
| Title | Localization of endogenous neurotrophins in two cortical regions and their role in neuron survival during vocal learning in zebra finch |
| Author | Quaglino, Allison |
| Author email | quaglino@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Neuroscience |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2007-03-19 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-03-28 |
| Advisor (committee chair) | Bottjer, Sarah |
| Advisor (committee member) |
[illegible] Watts, Alan G. Thompson, Richard S[illegible], C. Schlinger, Barney |
| Abstract | Vocal communication in animals is not uncommon; however few animals other than humans and songbirds learn their vocalizations during development (Hauser and Konishi, 1999). Humans and songbirds have highly complex neural circuitry dedicated to auditory processing and motor production to support this learned behavior (Doupe and Kuhl, 1999). The intriguing behavioral and neural similarities between song learning and human speech acquisition make the songbird a particularly useful animal model with which to better understand the mechanisms involved in vocal acquisition and production.; My research focuses on the role of neurotrophins in the survival of neurons during the ontogeny of the neural system that controls vocal learning in songbirds. Previous research in zebra finch, Taeniopygia guttata, has shown that LMAN, a cortical region which is necessary for song learning, sends projections to RA, a region in motor cortex which is necessary for song production. Early in development the axonal projections from LMAN to RA are remodeled, and appear to undergo substantial pruning to achieve a highly topographic organization by 35 days of age. Deafferentation of RA via removal of the LMAN to RA projecting axons, results in substantial cell death of RA neurons at 20 days of age. This deafferentation-induced cell death can be prevented by infusions of exogenous neurotrophins directly into RA. The first study presented here provides a descriptive survey of the endogenous expression of neurotrophins in RA and LMAN at 20, 40 and 60 days of age. The second study investigates, in vivo, if one or more of these endogenous neurotrophins are necessary for survival of RA neurons during early vocal learning. |
| Keyword | neurotrophin |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m335 |
| Rights | Quaglino, Allison |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Quaglino-20070328 |
| Archival file | uscthesesreloadpub_Volume17/etd-Quaglino-20070328.pdf |
Description
| Title | Page 1 |
| Full text | LOCALIZATION OF ENDOGENOUS NEUROTROPHINS IN TWO CORTICAL REGIONS AND THEIR ROLE IN NEURON SURVIVAL DURING VOCAL LEARNING IN ZEBRA FINCH by Allison Quaglino _____________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (NEUROSCIENCE) May 2007 Copyright 2007 Allison Quaglino |
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