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CLASSICAL EYEBLINK CONDITIONING:
THE ROLE OF THE CEREBELLUM AND ITS MOLECULAR BASES
by
Soyun Kim
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(NEUROSCIENCE)
May 2010
Copyright 2010 Soyun Kim
Object Description
| Title | Classical eyeblink conditioning: the role of the cerebellum and its molecular bases |
| Author | Kim, Soyun |
| Author email | soyunkim@usc.edu; neuroskim@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Neuroscience |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2010-03-24 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-05-03 |
| Advisor (committee chair) | Thompson, Richard F. |
| Advisor (committee member) |
Baudry, Michel Swanson, Larry Arbeitman, Michelle Madigan, Stephen |
| Abstract | The question of where and how memories are stored is one of the major interests in the field of neuroscience. Among the different brain structures investigated for localization of memory formation, such as hippocampus and amygdala, the cerebellum has been widely accepted as serving the neural basis for classical eyeblink conditioning. A growing body of evidence suggests that both cerebellar cortex and deep nuclei contribute to learning and memory of eyeblink conditioning. In this study, the role of the mammalian cerebellum was extensively examined in a novel mice model system with Purkinje cell deficiency. Glucose-regulated protein (GRP, 78kDa) conditional knockout mice demonstrated impaired learning with aberrant timing and amplitude of the conditioned response, and the interpositus nucleus was found to be crucial for expression of conditioned response. In addition, the molecular mechanism of cerebellar learning was investigated using immediate-early gene protein detection in the rat cerebellum following a single training session of eyeblink conditioning. c-Fos protein, a regulatory transcription factor, was detected in the Purkinje cells of the rat cerebellum perfused 1 hour after the onset of training. Activity-regulated cytoskeletal-associated protein (Arc) was significantly increased in the cerebellar cortex when compared to naïve or pseudoconditioned animals. Also, Stargazin expression was increased following training, which reinforces the notion that Stargazin is required for synaptic plasticity and learning and memory. Together, these studies extend previous findings of the role of cerebellum and the molecular dynamics underlying the establishment of memory trace in the mammalian cerebellum. |
| Keyword | classical eyeblink conditioning; learning and memory |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2982 |
| Rights | Kim, Soyun |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-KIM-3561 |
| Archival file | uscthesesreloadpub_Volume40/etd-KIM-3561.pdf |
Description
| Title | Page 1 |
| Full text | CLASSICAL EYEBLINK CONDITIONING: THE ROLE OF THE CEREBELLUM AND ITS MOLECULAR BASES by Soyun Kim A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (NEUROSCIENCE) May 2010 Copyright 2010 Soyun Kim |
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