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DEXA MEASURES OF BODY FAT PERCENTAGE AND ACUTE PHASE PROTEINS AMONG BREAST CANCER SURVIVORS
by Anne Dee
A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATICS AND EPIDEMIOLOGY) May 2010
Copyright 2010
Anne Dee
Object Description
| Title | DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors |
| Author | Dee, Anne |
| Author email | adee@usc.edu; needane@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Applied Biometry & Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2010-04-19 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-05-04 |
| Advisor (committee chair) |
McKean-Cowdin, Roberta Azen, Stanley Paul |
| Advisor (committee member) | Wu, Anna |
| Abstract | Objective: To examine the association between body fat percentage as measured by DEXA and 2 systemic inflammatory markers, C-reactive protein (CRP) and Serum amyloid A protein (SAA) in breast cancer survivors and its modulation by lifestyle factors.; Design: Cross-sectional measures from a longitudinal study of breast cancer survivors.; Subjects: 138 non-Hispanic White and Hispanic breast cancer survivors participating in the Washington and New Mexico components of the Health, Eating, Activity, and Lifestyle (HEAL) Study.; Measures: DEXA measures of body fat percentage and circulating levels of 2 acute phase proteins (CRP, SAA) approximately 30 months after breast cancer diagnosis.; Results: Circulating levels of CRP and SAA were associated with increased adiposity as measured by DEXA. Breast cancer patients with body fat ≥35% had significantly higher CRP and SAA levels compared to non-obese patients. The data suggest that geometric mean levels of CRP are lower among obese women taking non-steroidal anti-inflammatory drugs (NSAIDs) compared to obese women not taking them and higher among women eating ≥ 1500 kcal/day, although neither of these associations was statistically significant. Physical activity and other lifestyle factors were not significant modifiers of the associations of CRP and SAA with percentage body fat.; Conclusion: Women with body fat ≥35% had higher mean levels of systemic inflammatory markers than women with lower body fat. Modest changes in lifestyle (e.g. taking NSAIDs or decreasing caloric intake ) may help to reduce circulating inflammatory markers, which may beneficially impact survival. |
| Keyword | obesity; body fat percentage; DEXA; cancer |
| Geographic subject (county) | Los Angeles |
| Geographic subject (state) | New Mexico; Washington; California |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2989 |
| Contributing entity | University of Southern California |
| Rights | Dee, Anne |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-Dee-3663 |
| Archival file | uscthesesreloadpub_Volume35/etd-Dee-3663.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | DEXA MEASURES OF BODY FAT PERCENTAGE AND ACUTE PHASE PROTEINS AMONG BREAST CANCER SURVIVORS by Anne Dee A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATICS AND EPIDEMIOLOGY) May 2010 Copyright 2010 Anne Dee |
