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GENETIC CORRELATES OF THE TIMING OF NATURAL MENOPAUSE: THE BREAST AND PROSTATE CANCER COHORT CONSORTIUM
by
Tao Feng
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
May 2010
Copyright 2010 Tao Feng
Object Description
| Title | Genetic correlates of the timing of natural menopause: the breast and prostate cancer cohort consortium |
| Author | Feng, Tao |
| Author email | taof@usc.edu; tafeng@coh.org |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2010-03-24 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-04-27 |
| Advisor (committee chair) | Azen, Stanley |
| Advisor (committee member) |
Mack, Wendy Bernstein, Leslie Henderson, Katherine |
| Abstract | The timing of natural menopause is an important breast cancer risk factor. Several epidemiological studies suggest that the timing of natural menopause has a strong genetic component. We used existing genotype data from BPC3 to investigate the association between common genetic variation in the form of SNPs in three candidate genes (GNRH1, GNRHR, FSHB) and the timing of natural menopause. For FSHB, subjects carrying the heterozygous (CT) genotype (OR, 1.61, 95% CI: 1.15-2.25) of rs601681 had a nominally statistically significant increased risk of later age at natural menopause in comparison to the CC genotype. Subjects carrying either the heterozygous (CT) genotype (OR, 1.74; 95% CI, 1.21-2.50) or the homozygous recessive (TT) genotype (OR, 1.56; 95% CI, 1.02-2.37) of rs6169 had a nominally statistically significant increased risk of later age at natural menopause in comparison to the CC genotype. These findings may highlight an important genetic determinant of menopausal timing. |
| Keyword | GNRH1; GNRHR; FSHB; genetic correlates; timing of natural menopause; BPC3; case control study |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2963 |
| Rights | Feng, Tao |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Feng-3669 |
| Archival file | uscthesesreloadpub_Volume29/etd-Feng-3669.pdf |
Description
| Title | Page 1 |
| Full text | GENETIC CORRELATES OF THE TIMING OF NATURAL MENOPAUSE: THE BREAST AND PROSTATE CANCER COHORT CONSORTIUM by Tao Feng A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) May 2010 Copyright 2010 Tao Feng |
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