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CALPAIN IS BACK: A HYPOTHESIS REVISITED
by
Sohila Zadran
_____________________________________________________________________________________
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(NEUROSCIENCE)
May 2010
Copyright 2010 Sohila Zadran
Object Description
| Title | Calpain is back: a hypothesis revisited |
| Author | Zadran, Sohila |
| Author email | zadran@usc.edu; lillium@usa.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Neuroscience |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2010-03-03 |
| Date submitted | 2010 |
| Restricted until | Unrestricted |
| Date published | 2010-04-02 |
| Advisor (committee chair) | Baudry, Michel |
| Advisor (committee member) |
Thompson, Richard Madigan, Stephen |
| Abstract | In 1984, a hypothesis was proposed that boldly attempted to describe the cellular processes of learning and memory. This hypothesis implicated a protease, calpain, in initiating the restructuring of neuronal synapses following long term potentiation (LTP) or LTP-like stimulation. The authors hypothesized that this calpain-mediated restructuring of the synapse was the underlying mechanism of learning, memory formation and possibly memory consolidation. Since then, this hypothesis underwent constant scrutiny, falling in and out of favor until dissipating into the classical literature for several decades. Recently, several studies have revealed critical data about the calpain system; illuminating new aspects of the mechanisms of calpain activation in the central nervous system (CNS) and revitalizing the debate of the exact role of the calpain system in learning and memory. This project elucidates novel molecular machinery involved in calpain-mediated restructuring of the synapse following both growth factor stimulation and LTP-like stimulation, emanating from the receptor activation down to the subcellular molecular transformation. With the identification of this novel molecular machinery, this project hopes to also finally understand the enigma that is the biochemistry of learning and memory. |
| Keyword | calpain; synaptic plasticity; FRET, |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2893 |
| Rights | Zadran, Sohila |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Zadran-3549 |
| Archival file | uscthesesreloadpub_Volume23/etd-Zadran-3549.pdf |
Description
| Title | Page 1 |
| Full text | CALPAIN IS BACK: A HYPOTHESIS REVISITED by Sohila Zadran _____________________________________________________________________________________ A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (NEUROSCIENCE) May 2010 Copyright 2010 Sohila Zadran |
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