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SURFACE MODIFICATION OF NANOMATERIALS
AND DEVELOPMENT OF NANOBIOSENSORS
by
Marco Curreli
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(CHEMISTRY)
May 2010
Copyright 2010 Marco Curreli
Object Description
| Title | Surface modification of nanomaterials and developments of nanobiosensors |
| Author | Curreli, Marco |
| Author email | marcocurreli@gmail.com; curreli@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Chemistry |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2010-01-29 |
| Date submitted | 2010 |
| Restricted until | Restricted until 12 Feb. 2012. |
| Date published | 2012-02-12 |
| Advisor (committee chair) | Thompson, Mark E. |
| Advisor (committee member) |
Brutchey, Richard Mansfeld, Florian |
| Abstract | Semiconducting nanomaterials are strong candidates for sensing applications because of their high surface to volume ratio. During my doctorate studies, I contributed to the development of nanobiosensors, sensor devices based on field effect transistors that utilize these nanomaterials as the sensing element in the device. I was particularly involved in the surface modification of such nanomaterials.; Chapter One introduces nanobiosensors and discusses how certain factors related to the device fabrication or experimental conditions influence the sensitivity, selectivity, and settling time of sensor devices during the real time detection of biomolecules.; Chapter Two investigates the surface modification of carbon nanotubes. Several methods were explored to address certain practical problems: a chemical method based on the coordination of Cp*-Ru to the nanotube sidewalls resulted in the covalent functionalization of nanotubes and introduction of dopants; and the electrochemical-mediated addition of diazonium derived radicals. A related project involved investigating an electrochemical method for the selective functionalization of nanotube-based FET devices.; Chapter Three explores the surface modification of indium oxide nanowires. Linker bifunctional molecules based on phosphonate derivatives were found to strongly bind to the indium oxide surface. Moreover, a method for the electrochemical, selective functionalization of In2O3 based FETs was investigated.; Chapter Four details improvements to the overall process facilitating the real time detection of biomolecules. These improvements include: growing nanowires under controlled and reproducible conditions; testing devices in an automated fashion using a testing station consisting of our own semiconductor parameter analyzer, switch matrix, microfluidic accessories, among other components; and developing data analysis software and a database.; Chapter Five explores the real time detection of biological molecules, specifically the detection of biomarkers for two classes of malignancy: cancer and infectious diseases. My research team was the first to demonstrate the detection of a cancer biomarker (PSA) using FET nanobiosensors in a complementary fashion (using n-type and p-type semiconductors). Our devices have also detected a biomarker related to the highly contagious SARS’ coronavirus. Indium oxide nanowire devices were configured using surface chemistry technique I developed.; Chapter Six provides concluding remarks. |
| Keyword | nanowire biosensors; nanotube biosensors; cancer nanotechnology; nanomaterial surface modification |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2848 |
| Rights | Curreli, Marco |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Curreli-3473 |
| Archival file | uscthesesreloadpub_Volume29/etd-Curreli-3473.pdf |
Description
| Title | Page 1 |
| Full text | SURFACE MODIFICATION OF NANOMATERIALS AND DEVELOPMENT OF NANOBIOSENSORS by Marco Curreli A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (CHEMISTRY) May 2010 Copyright 2010 Marco Curreli |
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