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HORMONAL AND GENETIC RISK FACTORS OF ENDOMETRIAL CANCER
AND TRENDS IN INCIDENCE AND SURVIVAL OF ADULT ACUTE
LYMPHOBLASTIC LEUKEMIA
by
Pedram Razavi
_______________________________________________________________________
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(EPIDEMIOLOGY)
December 2009
Copyright 2009 Pedram Razavi
Object Description
| Title | Hormonal and genetic risk factors of endometrial cancer and trends in incidence and survival of adult acute lymphoblastic leukemia |
| Author | Razavi, Pedram |
| Author email | prazavi@usc.edu; prazavi@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2009-09-17 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-11-24 |
| Advisor (committee chair) | Ursin, Giske |
| Advisor (committee member) |
Pike, Malcolm C. McKean-Cowdin, Roberta Spicer, Darcy V. |
| Abstract | This dissertation consists of three chapters:; The first chapter examines the association between lifetime postmenopausal hormone therapy (HT) use and risk of endometrial cancer using data from a case-control study of invasive endometrial cancer nested within the California Teachers Study (CTS) cohort. In this chapter, I summarize the current literature describing the effect of HT on endometrial cancer. I then present the findings for an analysis of HT and endometrial cancer in the CTS, with new detail on the type of combination therapy. This manuscript has been accepted with minor changes for publication in Cancer Epidemiology, Biomarkers & Prevention.; The second chapter describes the potential impact of genetic and environmental factors on endometrial cancer risk. The analysis focuses on genetic variants in a select number of genes in the sex hormone metabolism pathway and risk of endometrial cancer. I further examine the modifying effect of these variants on the risk of endometrial cancer associated with different HT regimens.; The third chapter examines patterns of incidence and survival for adult acute lymphoblastic leukemia (ALL) by racial/ethnic groups. Data for these analyses came from the National Cancer Institute, Survival, Epidemiology, and End Results (SEER) database. Previous studies have suggested overall lower survival for some racial/ethnic groups compared to others. We further explore survival patterns by race, ALL subtype and age in the SEER data, which has not been well characterized in the literature. |
| Keyword | acute lymphoblastic leukemia; race; ethnicity; hispanic; survival; incidence eate; body mass index; endometrial cancer; single nucleotide polymorphism; haplotype; postmenopausal hormone therapy; estrogen; progestin |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2763 |
| Contributing entity | University of Southern California |
| Rights | Razavi, Pedram |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Razavi-3356 |
| Archival file | uscthesesreloadpub_Volume26/etd-Razavi-3356.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | HORMONAL AND GENETIC RISK FACTORS OF ENDOMETRIAL CANCER AND TRENDS IN INCIDENCE AND SURVIVAL OF ADULT ACUTE LYMPHOBLASTIC LEUKEMIA by Pedram Razavi _______________________________________________________________________ A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (EPIDEMIOLOGY) December 2009 Copyright 2009 Pedram Razavi |
