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A CROSS-SECTIONAL EXAMINATION: IMPACT OF DIET AND PHYSICAL
ACTIVITY ON PLASMA GLUCOSE METABOLISM, INSULIN SENSITIVITY AND
PANCREATIC Β-CELL FUNCTION IN HISPANIC WOMEN WITH HISTORIES OF
GESTATIONAL DIABETES MELLITUS
by
Xinwen Liu
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2009
Copyright 2009 Xinwen Liu
Object Description
| Title | A cross-sectional examination: impact of diet and physical activity on plasma glucose metabolism, insulin sensitivity and pancreatic β-cell function in Hispanic women with histories of gestational diabetes mellitus |
| Author | Liu, Xinwen |
| Author email | xinwenli@usc.edu; xinwenliu@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2009-10-22 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-11-30 |
| Advisor (committee chair) |
Xiang, Anny Azen, Stanley |
| Advisor (committee member) | Buchanan, Thomas |
| Abstract | The association between diet or physical activity (PA) and insulin sensitivity (IS), as well as β-cell function (BCF), has not been adequately examined. The purpose of the study is to cross-sectionally investigate this association in women with a history of gestational diabetes mellitus (GDM). Demographics, diet and PA data were collected using questionnaires; glucose metabolic measures (GMM) by OGTT and IVGTT. Among the 127 Hispanic women included in this report, we observed statistically significant differences in BMI and GMM between the 102 GDM patients and 25 controls; however, no differences were found in diet/PA. Diets high in carbohydrate, zinc, calcium and vitamin D seemed to be correlated with improved glucose control, IS and BCF. In addition, these beneficial effects were seen for exercise alone. These results highlight the importance of exercise in improving IS and BCF in women with a history of GDM to prevent the development of T2DM. |
| Keyword | plasma glucose metabolism; insulin sensitivity; pancreatic β-cell function; gestational diabetes mellitus; type 2 diabetes mellitus; diet; physical activity; sedentary time; exercise; Hispanic women; high risk |
| Geographic subject (county) | Los Angeles |
| Coverage date | 1993/1995 |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2736 |
| Rights | Liu, Xinwen |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Liu-1771 |
| Archival file | uscthesesreloadpub_Volume48/etd-Liu-1771.pdf |
Description
| Title | Page 1 |
| Full text | A CROSS-SECTIONAL EXAMINATION: IMPACT OF DIET AND PHYSICAL ACTIVITY ON PLASMA GLUCOSE METABOLISM, INSULIN SENSITIVITY AND PANCREATIC Β-CELL FUNCTION IN HISPANIC WOMEN WITH HISTORIES OF GESTATIONAL DIABETES MELLITUS by Xinwen Liu A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) December 2009 Copyright 2009 Xinwen Liu |
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