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STUDIES OF NANOSECOND PULSED POWER FOR MODIFICATIONS OF
BIOMATERIALS AND NANOMATERIALS (SWCNT)
By
Meng-Tse Chen
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(MATERIALS SCIENCE)
December 2009
Copyright 2009 Meng-Tse Chen
Object Description
| Title | Studies of nanosecond pulsed power for modifications of biomaterials and nanomaterials (SWCNT) |
| Author | Chen, Meng-Tse |
| Author email | mengtsec@usc.edu; mongao5429@hotmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Materials Science |
| School | Viterbi School of Engineering |
| Date defended/completed | 2009-09-21 |
| Date submitted | 2009 |
| Restricted until | Restricted until 22 Apr. 2010. |
| Date published | 2010-04-22 |
| Advisor (committee chair) | Gundersen, Martin A. |
| Advisor (committee member) |
Goo, Edward Zhou, Chongwu |
| Abstract | This work investigates the modification of biological materials through the applications of modern nanosecond pulsed power, along with other forms of nanotechnologies. The work was initially envisaged as a study of the effect of intense nanosecond pulsed electric fields on cancer cells. As the work progressed, the studies suggested incorporation of additional technologies, in particular, cold plasmas, and carbon nanotubes. The reasons for these are discussed below, however, they were largely suggested by the systems that we were studying, and resulted in new and potentially important medical therapies. Using nanosecond cold plasmas powered with nanosecond pulses, collaboration with endodontists and biofilm experts demonstrated a killing effect on biofilms deep within root canals, suggesting a fundamentally new approach to an ongoing problem of root canal sterilization. This work derived from the application of nanosecond pulsed power, resulting in effective biofilm disinfection, without excessive heating, and is being investigated for additional dental and other medical applications. In the second area, collaboration with medical and nanotube experts, studies of gliomamultiforme (GBM) led to the incorporation of functionalized carbon nanotubes. Single-walled carbon nanotube-fluorescein carbazide(SWCNT-FC) conjugates demonstrated that the entry mechanism of the single-walled carbon nanotubes(SWCNTs)was through an energy-dependent endocytotic pathway. Finally, a monotonic pH sensitivity of the intracellular fluorescence emission of SWCNT-FC conjugates in human ovarian cancer cells suggests these conjugates may serve as intracellular pH sensors. Light-stimulated intracellular hydrolysis of the amide linkage and localized intracellular pH changes are proposed as mechanisms. The use of SWCNTs for cancer therapy of gliomas, resulting in hyperthermia effect after 808 nm infrared radiations, absorbed specifically by SWCNTs but not by biological tissue.; Heat was only observed to kill cells containing intracellular SWCNTs. Furthermore, intracellular SWCNTs also cause aggregation and clustering of the cells, and a reduced ability of the cells to attach to and migrate over a substrate. This phenomenon has the potential to reduce the multiplication, migration, and invasion of brain cancer cells into the surrounding tissue. |
| Keyword | nanosecond pulsed power; cold plasma; root canal disinfection; carbon nanotubes; pH sensor; migration reduction; brain tumor therapy |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2681 |
| Rights | Chen, Meng-Tse |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Chen-3275 |
| Archival file | uscthesesreloadpub_Volume29/etd-Chen-3275.pdf |
Description
| Title | Page 1 |
| Full text | STUDIES OF NANOSECOND PULSED POWER FOR MODIFICATIONS OF BIOMATERIALS AND NANOMATERIALS (SWCNT) By Meng-Tse Chen A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (MATERIALS SCIENCE) December 2009 Copyright 2009 Meng-Tse Chen |
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