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RISKY HEALTH BEHAVIORS AND NEUROCOGNITIVE FUNCTION AMONG
PEOPLE LIVING WITH HIV
by
Pamela Johnson
A Thesis Presented to the
FACULTY OF USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2009
Copyright 2009 Pamela Johnson
Object Description
| Title | Risky health behaviors and neurocognitive function among people living with HIV |
| Author | Johnson, Pamela |
| Author email | pamelalj@usc.edu; iamplj@yahoo.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2009-10-28 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-11-11 |
| Advisor (committee chair) | Richardson, Jean |
| Advisor (committee member) |
Milam, Joel Berhane, Kiros |
| Abstract | Data from the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapies were examined to assess whether there are associations between neurocognitive functioning and risky behaviors among people living with HIV. Among the 658 HIV positive study participants examined, median age was 41 years; 57% were white, 32% were black, and 11% were Hispanic or of another ethnicity; 77% were male; 53% were men who have sex with men; median baseline cd4 count was 464 cells/mm3; 78% had a viral load <400 copies/ml; 82% were on an antiviral regimen; 32% reported heavy drinking; 41% were current smokers; 25% were marijuana users; 25% reported using illicit drugs. Multivariate models were constructed for 5 cognitive assessments to examine associations with unsafe sexual behaviors, number of sexual partners, and substance use. A higher viral load was associated with a lower performance onidentification (visual attention) and monitoring (divided attention) (p<.001). Having sex with two or more partners in the previous 3 months was associated with a higher monitoring score (p=.03). For Detection (psychomotor function), there was a significant interaction between marijuana use in the previous 30 days and heavy drinking (p=.01), indicating that those who used both substances scored better than those who only smoked marijuana or drank heavily. Males performed better than females on all 5 of the tasks. |
| Keyword | HIV; substance abuse; neurocognitive function; neurocognitive impairment; risky sexual behaviors; biostatistics |
| Geographic subject (city or populated place) | Denver; Minneapolis; Providence; St. Louis |
| Geographic subject (country) | USA |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2730 |
| Rights | Johnson, Pamela |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Johnson-3385 |
| Archival file | uscthesesreloadpub_Volume23/etd-Johnson-3385.pdf |
Description
| Title | Page 1 |
| Full text | RISKY HEALTH BEHAVIORS AND NEUROCOGNITIVE FUNCTION AMONG PEOPLE LIVING WITH HIV by Pamela Johnson A Thesis Presented to the FACULTY OF USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) December 2009 Copyright 2009 Pamela Johnson |
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