Page 1 |
Save page Remove page | Previous | 1 of 245 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
PET STUDY OF RETINAL PROSTHESIS FUNCTIONALITY
by
John Zhong Xie
A Dissertation Presented to the
FACULTY OF THE USC VITERBI SCHOOL OF ENGINEERING
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirement for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
December 2009
Copyright 2009 John Zhong Xie
Object Description
| Title | PET study of retinal prosthesis functionality |
| Author | Xie, John Zhong |
| Author email | jianxie@usc.edu; jian_xie@hotmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2009-08-11 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-09-08 |
| Advisor (committee chair) | Humayun, Mark |
| Advisor (committee member) |
Weiland, James Jadvar, Hossein Singh, Manbir Khoo, Michael Sampath, Alapakkam |
| Abstract | Objective measures that demonstrate activation of the retina, primary visual cortex, and possibly higher cortical association areas are necessary to illustrate the functionality of retinal prosthesis in sight-impaired subjects who have been implanted with such a device. Neural remodeling that occurs in outer retinal degenerative diseases can have an impact on the usefulness of retinal prostheses.; In this project we use quantitative positron emission tomography (PET) method coupled with metabolic radiotracer 18F-fluorodeoxyglucose (FDG) to evaluate brain activation under light stimulation and transcorneal electrical stimulation (TcES) conditions in normal sighted controls and subjects with retinal degeneration (RD). Both light stimulation and TcES resulted in activation of primary (BA 17) and secondary visual cortex (BA 18 and 19) in RD subjects. Transcorneal electrical stimulation using ERG-Jet corneal electrode resulted in similar subjective phosphene sensation in the right peripheral visual field for both normal and RD subjects, and this led to retinotopically matched primary visual cortex activation in both subject groups. Higher-level visual processing areas that are involved in object vision (inferior temporal gyrus, BA 20; fusiform gyrus, BA 37) and visual memory (parahippocampal gyrus, BA 27) are not significantly activated in RD subjects during both light and transcorneal electrical stimulation as they are in normal controls.; This study objectively demonstrates electrical stimulation of the retina can activate visual cortex and lead to visual perception in retinal degeneration subjects and establishes a basis for assessing retinal prosthesis functionality in vivo. |
| Keyword | PET; positron emission tomography; quantitative PET; functional imaging; retinal prosthesis; light stimulation; transcorneal electrical stimulation; retinal degenerative diseases; visual cortex plasticity; blindness |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2591 |
| Rights | Xie, John Zhong |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Xie-3229 |
| Archival file | uscthesesreloadpub_Volume40/etd-Xie-3229.pdf |
Description
| Title | Page 1 |
| Full text | PET STUDY OF RETINAL PROSTHESIS FUNCTIONALITY by John Zhong Xie A Dissertation Presented to the FACULTY OF THE USC VITERBI SCHOOL OF ENGINEERING UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirement for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) December 2009 Copyright 2009 John Zhong Xie |
Comments
Post a Comment for Page 1
