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IMPACT OF SURGERY ON HEALTH-RELATED QUALITY OF LIFE
IN PATIENTS WITH ACOUSTIC NEUROMA
by
Connie Xiaoyin Wu
________________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2006
Copyright 2006 Connie Xiaoyin Wu
Object Description
| Title | Impact of surgery on health-related quality of life in patients with acoustic neuroma |
| Author | Wu, Connie Xiaoyin |
| Author email | conniewu@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2006-11-01 |
| Date submitted | 2006 |
| Restricted until | Unrestricted |
| Date published | 2006-11-06 |
| Advisor (committee chair) | Mack, Wendy J. |
| Advisor (committee member) |
Azen, Stanley Fisher, Laurel M. |
| Abstract | This thesis presents a multivariate evaluation of health-related quality of life (QOL) after acoustic neuroma surgery in a longitudinal study. Multiple regression is utilized to estimate the impact of surgery on QOL given hearing loss, facial impairment and physical pain symptoms. Different instruments of QOL are investigated using path analysis with facial function at discharge to form flexible cause-effect models. Facial function at discharge is associated with facial symptoms and physical pain, which in turn correlated with poor QOL. The analyses also suggest that restricted facial nerve function is the most disabling symptom postoperatively (p<0.0001, R2=0.54). Gender, age, tumor size and clinical symptom of hearing loss did not have an effect on QOL. This study provides the knowledge necessary to design and improve QOL research in acoustic neuroma. |
| Keyword | acoustic neuroma; quality of life; path analysis |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m123 |
| Rights | Wu, Connie Xiaoyin |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Wu-20061106 |
| Archival file | uscthesesreloadpub_Volume35/etd-Wu-20061106.pdf |
Description
| Title | Page 1 |
| Full text | IMPACT OF SURGERY ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH ACOUSTIC NEUROMA by Connie Xiaoyin Wu ________________________________________________________ A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) December 2006 Copyright 2006 Connie Xiaoyin Wu |
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