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LOCATION OF LESIONS ON POSTMORTEM BRAIN BY CO-REGISTERING
CORRESPONDING MRI AND POSTMORTEM SLICES
by
Amrita Rajagopalan
A Thesis Presented to the
FACULTY OF THE VITERBI SCHOOL OF ENGINEERING
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOMEDICAL ENGINEERING)
December 2006
Copyright 2006 Amrita Rajagopalan
Object Description
| Title | Location of lesions on postmortem brain by co-registering corresponding MRI and postmortem slices |
| Author | Rajagopalan, Amrita |
| Author email | arajagop@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2006-10-17 |
| Date submitted | 2006 |
| Restricted until | Unrestricted |
| Date published | 2006-10-30 |
| Advisor (committee chair) | Singh, Manbir |
| Advisor (committee member) |
Maarek, Jean-Michel Nayak, Krishna |
| Abstract | Brain vascular abnormalities like lacunar infarcts and perivascular spaces cannot be readily identified on MRI images but can be recognized on postmortem slices. We present a method for transferring information from MRI images to the corresponding postmortem images in order to validate the diagnosis of vascular lesions from MRI. We achieve this by co-registering the in-vivo MRI with digital photographs of the postmortem brain and transferring marked lesions from the registered MRI to the postmortem images. Relatively larger samples of the postmortem slices around these marks are extracted and sent to a pathologist to identify abnormalities by histological methods. To validate the co-registration, the histologically identified regions are manually registered to the original postmortem images. Results reveal that the co-registration identifies the locations of 11 lesions in 7 subjects within an error of 7.6±2.6 mm. |
| Keyword | postmortem brain; polynomial registration |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m115 |
| Rights | Rajagopalan, Amrita |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Rajagopalan-20061030 |
| Archival file | uscthesesreloadpub_Volume32/etd-Rajagopalan-20061030.pdf |
Description
| Title | Page 1 |
| Full text | LOCATION OF LESIONS ON POSTMORTEM BRAIN BY CO-REGISTERING CORRESPONDING MRI AND POSTMORTEM SLICES by Amrita Rajagopalan A Thesis Presented to the FACULTY OF THE VITERBI SCHOOL OF ENGINEERING UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOMEDICAL ENGINEERING) December 2006 Copyright 2006 Amrita Rajagopalan |
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