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SYNTHETIC STUDIES OF PHOSPHONATE DERIVATIVES
by
Gregorio Valentin Sanchez, Jr.
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(CHEMISTRY)
December 2006
Copyright 2006 Gregorio Valentin Sanchez, Jr.
Object Description
| Title | Synthetic studies of phosphonate derivatives |
| Author | Sanchez, Gregorio Valentin, Jr. |
| Author email | gregoris@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Chemistry |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2006-01-01 |
| Date submitted | 2006 |
| Restricted until | Unrestricted |
| Date published | 2006-10-19 |
| Advisor (committee chair) | McKenna, Charles E. |
| Advisor (committee member) |
Barrios, Amy Tower, John |
| Abstract | Pyrophosphonate analogs such as methylenebisphosphonates and phosphonoacetates have applications in pharmaceutical chemistry and also in material sciences. Herein, a series of synthetic studies focusing on the preparation of potentially useful new organophosphorus compounds are presented. In Chapter 1, the addition of organometallic reagents to carbonylbisphosphonate and oxophosphonoacetate alkyl esters to generate a-hydroxy, a-substituted methylenebisphosphonate or phosphonoacetate alkyl esters is investigated. Chapter 2 discusses synthetic approaches to branched (E)-(hydroxyimino)(dihydroxyphosphinyl)acetic acid ligands and their possible application as metal chelating agents. Finally, Chapter 3 presents the hypochlorite oxidation of diazomethylenebisphosphonate alkyl esters with various alcohols for use in synthesis of nucleoside 5'-triphosphate carbonylbisphosphonate analogs. |
| Keyword | organometallic chemistry; phosphonates; bisphosphonates; metal chelating agents; osteoporosis; anti-viral agents; nucleoside analogs |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m99 |
| Rights | Sanchez, Gregorio Valentin, Jr. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Sanchez-20061019 |
| Archival file | uscthesesreloadpub_Volume29/etd-Sanchez-20061019.pdf |
Description
| Title | Page 1 |
| Full text | SYNTHETIC STUDIES OF PHOSPHONATE DERIVATIVES by Gregorio Valentin Sanchez, Jr. A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (CHEMISTRY) December 2006 Copyright 2006 Gregorio Valentin Sanchez, Jr. |
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