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DYNAMIC CARDIOVASCULAR MAGNETIC RESONANCE IMAGING FOR
IMPROVED ASSESSMENT OF ISCHEMIC HEART DISEASE
by
Taehoon Shin
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(ELECTRICAL ENGINEERING)
December 2009
Copyright 2009 Taehoon Shin
Object Description
| Title | Dynamic cardiovascular magnetic resonance imaging for improved assessment of ischemic heart disease |
| Author | Shin, Taehoon |
| Author email | shinage@gmail.com; taehoons@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Electrical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2009-07-16 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-08-27 |
| Advisor (committee chair) | Nayak, Krishna |
| Advisor (committee member) |
Mendel, Jerry Pohost, Gerald Valero-Cuevas, Francisco |
| Abstract | Magnetic resonance imaging (MRI) is one of the most powerful non-invasive imaging modalities whose strengths include flexible tissue contrast, sensitivity to flow, and the lack of any harmful radiation. Ischemic heart disease (IHD) is a leading cause of death in the western world, and as such, MR approaches for the assessment of IHD have gained considerable attention. This dissertation will describe two improvements in cardiac MRI methodology that are aimed at improving the assessment of IHD: (i) Real-time cardiac imaging and (ii) First-pass myocardial perfusion imaging.; The first method, real-time cardiac MRI continuously captures the beating heart without the need for cardiac gating and breathhold, and is a promising approach for the assessment of ventricular function. Efficient k-space sampling trajectories (e.g., spiral or echo-planar) are typically used to reduce acquisition time, but further improvement in spatio-temporal resolution is desirable. A novel reconstruction method was developed for accelerating real-time spiral imaging, based on an algebraic reconstruction framework that can be applied to undersampled data. The method utilizes knowledge of the aliasing pattern caused by spiral undersampling, and the fact that temporal bandwidth of dynamic cardiac images is a function of spatial position.; The second method, first-pass myocardial perfusion imaging (MPI) is a tool for early detection of IHD by evaluating blood flow to the myocardium. The most widely used protocol for MR MPI involves a 2D multi-slice acquisition, which has demonstrated high sensitivity and specificity, but suffers from incomplete spatial coverage. We developed a three-dimensional MR MPI approach that allows contiguous and complete coverage of the left ventricle. We demonstrate its accuracy in a cardiac phantom, and its feasibility in several healthy volunteers. We also compare the performance of diastolic acquisition, which has a longer quiescent period and enables higher spatial resolution, versus systolic acquisition, which is less sensitive to heart-rate variation or arrhythmia. Achieving both complete coverage and high spatial resolution is challenging in 3D MPI. The last part of this dissertation focuses the use of regularized reconstruction, and how it may be used to improve spatial resolution. |
| Keyword | magnetic resonance imaging; cardiac MRI; real time imaging; myocardial perfusion imaging; ischemic heart disease |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2578 |
| Rights | Shin, Taehoon |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Shin-3045 |
| Archival file | uscthesesreloadpub_Volume29/etd-Shin-3045.pdf |
Description
| Title | Page 1 |
| Full text | DYNAMIC CARDIOVASCULAR MAGNETIC RESONANCE IMAGING FOR IMPROVED ASSESSMENT OF ISCHEMIC HEART DISEASE by Taehoon Shin A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (ELECTRICAL ENGINEERING) December 2009 Copyright 2009 Taehoon Shin |
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