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CYTOKINE LEVELS, MICROBIOLOGY, AND VIROLOGY
IN HEALTHY IMPLANTS AND TEETH
by
Sharon Phamduong
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CRANIOFACIAL BIOLOGY)
August 2009
Copyright 2009 Sharon Phamduong
Object Description
| Title | Cytokine levels, microbiology, and virology in healthy implants and teeth |
| Author | Phamduong, Sharon |
| Author email | sharondds@gmail.com; sharon02@ucla.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Cranio-Facial Biology |
| School | School of Dentistry |
| Date defended/completed | 2009-06-25 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-07-29 |
| Advisor (committee member) |
Nowzari, Hessam Rich, Sandra Navazesh, Mahvash |
| Abstract | Background: Peri-implant microbial infection elicit an immune response regulated by key cytokines controlling the progression and/or suppression of inflammation.; Purpose: To describe peri-implant levels of pro-inflammatory cytokines, microbiology, and virology in clinically healthy sites.; Methods: Implants and teeth were considered clinically healthy. No pocketing (≥4mm), no bleeding on probing (BOP), and no bone loss beyond the first thread was detected. Crevicular fluid sampling and cytokine analysis was quantified for IL-8, IL1-beta, IL-6, IL-10, TNF-alpha, and IL-12p70 using flow cytometry. Samples from paper points were processed for microbiological testing, DNA extraction, and real-time PCR for the detection of HCMV, HSV-1, and HSV-2.; Results: 15 implants and 16 teeth were evaluated for cytokine concentration and presence of periodontal pathogens. IL-6 was statistically greater in implants than in teeth. TNF-α also exhibited a strong trend for higher levels in implants than teeth.; Conclusions: Studies are needed to investigate pro-inflammatory cytokines produced in spite of minimal bacterial accumulation |
| Keyword | bone loss; cytokines; implants; inflammation; periodontology; viruses |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2407 |
| Rights | Phamduong, Sharon |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Phamduong-3133 |
| Archival file | uscthesesreloadpub_Volume44/etd-Phamduong-3133.pdf |
Description
| Title | Page 1 |
| Full text | CYTOKINE LEVELS, MICROBIOLOGY, AND VIROLOGY IN HEALTHY IMPLANTS AND TEETH by Sharon Phamduong A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CRANIOFACIAL BIOLOGY) August 2009 Copyright 2009 Sharon Phamduong |
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