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BMI-1 EXPRESSION INVERSELY CORRELATES WITH DIFFERENTIATION BUT
NOT CLINICAL OUTCOME OR CDKN2A EXPRESSION IN EWING SARCOMA
FAMILY OF TUMORS
by
John Anthony van Doorninck
___________________________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CLINICAL AND BIOMEDICAL INVESTIGATIONS)
August 2009
Copyright 2009 John Anthony van Doorninck
Object Description
| Title | BMI-1 expression inversely correlates with differentiation but not clinical outcome or CDKN2A expression in Ewing sarcoma family of tumors |
| Author | van Doorninck, John Anthony |
| Author email | jvandoorninck@chla.usc.edu; jvandoorninck@yahoo.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Preventive Medicine (Health Behavior) |
| School | Keck School of Medicine |
| Date defended/completed | 2009-03-18 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-07-11 |
| Advisor (committee chair) | Seeger, Robert |
| Advisor (committee member) |
Sposto, Richard Aldrovandi, Grace |
| Abstract | Ewing sarcoma family tumors (ESFT) are highly undifferentiated bone and soft tissue tumors that primarily affect children. Metastatic disease at diagnosis portends a worse prognosis and remains the only reliable predictor of outcome. The polycomb protein BMI-1 is associated with worse clinical outcome in some human cancers. This study evaluates the clinical and biologic significance of BMI-1 expression in ESFT.; Using immunohistochemical analysis, 80% of ESFT were found to robustly express BMI-1 in all tumor cells, while 15% lacked BMI-1 expression. Analysis of 79 tumors revealed no association between BMI-1 and clinical presentation, outcome, loss of p16 or mutation of p53. Significantly, however, BMI-1 levels were highly inversely correlated with markers of neural crest differentiation. Together these findings demonstrate that ESFT cells nearly universally express BMI-1 and suggest that high-level expression of BMI-1 underlies the highly undifferentiated phenotype that characterizes this tumor family. |
| Keyword | Ewing sarcoma; BMI-1; stem cell; CDKN2A; prognosis |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2350 |
| Rights | van Doorninck, John Anthony |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Doorninck-2672 |
| Archival file | uscthesesreloadpub_Volume17/etd-Doorninck-2672.pdf |
Description
| Title | Page 1 |
| Full text | BMI-1 EXPRESSION INVERSELY CORRELATES WITH DIFFERENTIATION BUT NOT CLINICAL OUTCOME OR CDKN2A EXPRESSION IN EWING SARCOMA FAMILY OF TUMORS by John Anthony van Doorninck ___________________________________________________________________ A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CLINICAL AND BIOMEDICAL INVESTIGATIONS) August 2009 Copyright 2009 John Anthony van Doorninck |
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