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Copyright 2009 Brooke Christine Basinger
MODELING RETINAL PROSTHESIS MECHANICS
by
Brooke Christine Basinger
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
May 2009
Object Description
| Title | Modeling retinal prosthesis mechanics |
| Author | Basinger, Brooke Christine |
| Author email | basinger@usc.edu; Brooke_Basinger@yahoo.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2009-03-18 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-05-11 |
| Advisor (committee chair) | Weiland, James D. |
| Advisor (committee member) |
Humayun, Mark S. Meng, Ellis Shiflett, Geoffrey |
| Abstract | Degenerative retinal diseases such as Retinitis Pigmentosa and Age-Related Macular Degeneration are, together, one of the leading causes of blindness in the United States. Retinal prostheses bypass the degenerated cells and apply electrical stimulation directly to the visual neural pathway, creating an artificial sensation of sight in subjects with retinal blindness. Current prostheses utilize a polymer electrode array, which is affixed to the retina using a retinal tack. The electrode array applies mechanical pressure to the retina, which can cause mechanical damage to the very cells which are required to transmit the applied signal. We can mitigate or relocate mechanical damage to the retina through electrode array design changes, but to do so, we must thoroughly understand the mechanical interface between the array and the retina.; I have generated a computerized model of the mechanical interaction of array and eye wall using solid modeling and Finite Element Analysis techniques. I describe and justify the choices made in the development of this model, define model inputs, provide results from ten studies, and validate the accuracy of model results through comparison to experimental data. This work is significant in that it combines a modifiable device and a complex series of biomaterials in the same model, demonstrating that it is feasible to satisfy the sometimes conflicting goals of product design and biomaterials modeling simultaneously. This model can now be used by retinal prosthesis developers to optimize electrode array design, reduce mechanical damage to the retina, and improve device efficacy. |
| Keyword | finite element analysis; solid modeling; medical device design; retinal prosthesis |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2231 |
| Rights | Basinger, Brooke Christine |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Basinger-2833 |
| Archival file | uscthesesreloadpub_Volume26/etd-Basinger-2833.pdf |
Description
| Title | Page 1 |
| Full text | Copyright 2009 Brooke Christine Basinger MODELING RETINAL PROSTHESIS MECHANICS by Brooke Christine Basinger A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) May 2009 |
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