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THE ROLE OF DNA METHYLATION IN EARLY DETECTION AND
PROGRESSION OF PANCREATIC CANCER
by
Shirley Oghamian
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOCHEMISTRY & MOLECULAR BIOLOGY)
May 2009
Copyright 2009 Shirley Oghamian
Object Description
| Title | The role of DNA methylation in early detection and progression of pancreatic cancer |
| Author | Oghamian, Shirley |
| Author email | oghamian@usc.edu; virenie21@yahoo.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2009-03-17 |
| Date submitted | 2009 |
| Restricted until | Restricted until 12 May. 2011. |
| Date published | 2011-05-12 |
| Advisor (committee member) |
Laird-Offringa, Ite A. Shibata, Darryl Stallcup, Michael R. |
| Abstract | Cancer is the second leading cause of death in the United States and each year nearly half a million Americans die of the disease. The high rate of mortality is often not caused by tumors at the site of origin. In most cases, the spreading of tumor to distant organs is the cause for multiple organ failure and ultimately death. Therefore, it is imperative that tumors are detected early enough, where surgical intervention or administration of chemotherapeutic agents can benefit the patient. Studies have shown that cancers that are detected at early stage have far better prognosis than ones that are detected at late stage. For this reason, a lot of attention is devoted to early detection of cancer. However, some types of cancer, such as pancreatic cancer, arise at poorly accessible sites and are therefore often diagnosed late with poor outcomes.; The focus of our research is to identify DNA methylation biomarkers that are specific for pancreatic cancer and to utilize newly developed technology for detecting these molecules in patient blood. We used both a candidate gene approach and a genome-wide approach to identify novel differentially methylated loci for pancreatic cancer detection. These techniques allowed us to identify a panel of markers that are methylated in malignant pancreatic tumors but are either devoid of or show very low levels of methylation in normal pancreas or benign pancreatic disease. The panel was then tested using blood from patients who underwent surgical procedures for pancreatic tumor resection. Current data demonstrates that detection of our top panel in patient blood is not established and further experimentation is necessary to understand our limitations. |
| Keyword | DNA methylation; pancreatic cancer; progression; early detection |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2244 |
| Rights | Oghamian, Shirley |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Oghamian-2772 |
| Archival file | uscthesesreloadpub_Volume29/etd-Oghamian-2772.pdf |
Description
| Title | Page 1 |
| Full text | THE ROLE OF DNA METHYLATION IN EARLY DETECTION AND PROGRESSION OF PANCREATIC CANCER by Shirley Oghamian A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOCHEMISTRY & MOLECULAR BIOLOGY) May 2009 Copyright 2009 Shirley Oghamian |
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