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TRANSCRIPTIONAL CO-ACTIVATION FUNCTIONS OF MSX HOMEODOMAIN
PROTEINS BY ACTIVATING HSF PROTEINS
by
Fengfeng Zhuang
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFIRNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(CRANIAOFACIAL BIOLOGY)
May 2008
Copyright 2008 Fengfeng Zhuang
Object Description
| Title | Transcriptional co-activation functions of Msx homeodomain proteins by activating Hsf proteins |
| Author | Zhuang, Fengfeng |
| Author email | fzhuang@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Cranio-Facial Biology |
| School | School of Dentistry |
| Date defended/completed | 2007-12-17 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-03-05 |
| Advisor (committee chair) | Shuler, Charles |
| Advisor (committee member) |
Liu, Yi-hsin Paine, Michael Oldak, Janet Moradian Kwfong, Henry |
| Abstract | The importance of Msx genes in regulating development of ocular, neuronal, cardiac, ectodermal and oro-craniofacial structures has been well established. Previous studies have shown that Msx proteins regulate gene transcription predominantly through repression by forming transcriptionally inactive heteromeric complexes. In contrast to their known suppressor activities, gene expression studies using either the gain-of-function or the loss-of-function mutants revealed many gene targets whose expression requires functional Msx proteins. Here we present data demonstrating for the first time that Msx proteins function as activators of transcription by controlling the intracellular distribution and by modulating the transcriptional activity of partnering molecules. Msx proteins activate the Hsp70 promoter through a mechanism in which Msx protein physically interacts with and modify Heat shock transcriptional factors (Hsfs) to facilitate their nuclear translocation, accumulation and subsequent transcriptional activation. The fact that Msx1 and Msx2 can stimulate Hsf mediated transcriptional activation of Hsp70 promoter in the absence of chemical, physical or physiological stress suggests that Msx1 and Msx2 may provide a critical and novel pathway in activating Hsf1 and Hsf2 and hence transcriptional induction of their target genes under normal physiological conditions. |
| Keyword | Msx1; Hsf; craniofacial biology |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1041 |
| Rights | Zhuang, Fengfeng |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-zhuang-20080305 |
| Archival file | uscthesesreloadpub_Volume23/etd-zhuang-20080305.pdf |
Description
| Title | Page 1 |
| Full text | TRANSCRIPTIONAL CO-ACTIVATION FUNCTIONS OF MSX HOMEODOMAIN PROTEINS BY ACTIVATING HSF PROTEINS by Fengfeng Zhuang A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFIRNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (CRANIAOFACIAL BIOLOGY) May 2008 Copyright 2008 Fengfeng Zhuang |
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