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MEAT INTAKE, POLYMORPHISMS IN THE NER AND MMR PATHWAYS AND COLORECTAL CANCER RISK
by
Amit Joshi
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(MOLECULAR EPIDEMIOLOGY)
May 2008
Copyright: 2008 Amit Joshi
Object Description
| Title | Meat intake, polymorphisms in the NER and MMR pathways and colorectal cancer risk |
| Author | Joshi, Amit |
| Author email | amitjosh@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Molecular Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2007-12-18 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-03-10 |
| Advisor (committee chair) | Stern, Mariana C. |
| Advisor (committee member) |
Ingles, Sue Conti, David |
| Abstract | Red meat intake has been associated with colorectal cancer (CRC) risk with some consistency and may result in exposure to carcinogens which can cause DNA damage. We investigated whether variation in NER and MMR (DNA repair) pathways affect CRC risk and modify the effect of meat intake, in a case-sibling study. We used conditional logistic regression models to assess CRC risk using the following exposure variables: frequency of red meat, cooked red meat and poultry, level of doneness of red meat from inside and outside and level of doneness of poultry. We tested for GxE interactions for all nine tested SNPs and exposure variables. Consumption of more than 3 servings of red meat or cooked red meat per week statistically significantly increased the risk of CRC. Case-only analysis suggested that the effect of red meat heavily brown in the inside or outside was modified by XPD-Lys751Gln SNP. |
| Keyword | cooked meat; colorectal neoplasms; proband-sibling study; nucleotide excision repair; mismatch repair; genetic variation; single nucleotide polymorphisms |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1040 |
| Rights | Joshi, Amit |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Joshi-20080310 |
| Archival file | uscthesesreloadpub_Volume23/etd-Joshi-20080310.pdf |
Description
| Title | Page 1 |
| Full text | MEAT INTAKE, POLYMORPHISMS IN THE NER AND MMR PATHWAYS AND COLORECTAL CANCER RISK by Amit Joshi A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (MOLECULAR EPIDEMIOLOGY) May 2008 Copyright: 2008 Amit Joshi |
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