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GENETIC REVIEW OF MOUSE AND HUMAN CLEFT LIP AND PALATE
by
Lesley Y. Jeong
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CRANIOFACIAL BIOLOGY)
May 2009
Copyright 2009 Lesley Y. Jeong
Object Description
| Title | Genetic review of mouse and human cleft lip and palate |
| Author | Jeong, Lesley Y. |
| Author email | LJEONG@usc.edu; lesleyjeong@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Cranio-Facial Biology |
| School | School of Dentistry |
| Date defended/completed | 2009-02-02 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-04-28 |
| Advisor (committee chair) | Chai, Yang |
| Advisor (committee member) |
Sameshima, Glenn Urata, Mark |
| Abstract | Background: Cleft lip and palate are common human birth defects which arise from many etiologies, including the following: genetic disorders, chromosomal abnormalities, teratogenic exposures, sporadic, and unknown causes. The causes are being tested through animal model studies. However, no previous review has specifically compared the morphology of mouse cleft palates with the same defect in humans.; Purpose: To compare the genetic causes similar to mice and humans. To test the hypothesis that the specific causes of mouse cleft are also identified in humans.; Summary: Mutations in TGFβ3, MSX1, IRF6, and P63 all cause cleft lip and or palate in humans. Only single sporadic human cases of mutations in TGFβ-IR, TGFβ-IIR, and PAX9 were found to be associated with clefting. This review validates the mouse model and contributes to a greater understanding of human craniofacial anomalies. |
| Keyword | mouse cleft lip and palate; human cleft lip and palate; comparative anatomy |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2150 |
| Rights | Jeong, Lesley Y. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Jeong-2655 |
| Archival file | uscthesesreloadpub_Volume32/etd-Jeong-2655.pdf |
Description
| Title | Page 1 |
| Full text | GENETIC REVIEW OF MOUSE AND HUMAN CLEFT LIP AND PALATE by Lesley Y. Jeong A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CRANIOFACIAL BIOLOGY) May 2009 Copyright 2009 Lesley Y. Jeong |
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