Page 1 |
Save page Remove page | Previous | 1 of 29 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
A RANDOMIZED, DOUBLE –BLIND,
PLACEBO-CONTROLLED PHASE ΙΙ TRIAL TO EXAMINE
THE EFFECT OF POLYPHENON E
ON ENDOGENOUS HORMONE LEVELS
by
Chen Ling
______________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(APPLIED BIOSTATISTICS AND EPIDEMIOLOGY)
May 2009
Copyright 2009 Chen Ling
Object Description
| Title | A randomized, double-blind, placebo-controlled phase II trial to examine the effect of Polyphenon E on endogenous hormone levels |
| Author | Ling, Chen |
| Author email | chenling@usc.edu; ling-c02@hotmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Applied Biostatistics & Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2009-03-22 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-04-22 |
| Advisor (committee chair) | Pike, Malcolm |
| Advisor (committee member) |
Wu, Anna Pearce, Celeste |
| Abstract | In this randomized, double-blind, placebo-controlled phase II trial to examine the effect of Polyphenon E [containing the most important polyphenol, epidgallocatechin gallate (EGCG) in green tea] on endogenous hormone profiles, 111 participants were recruited and randomized into three different experimental arms: 400 mg EGCG daily, 800 mg EGCG daily or placebo for a period of 60 days. Four steroid hormones: androstenedione (Andr), testosterone (T), estrone (E1) and estradiol (E2), and two protein hormones: adiponectin (Adip) and insulin-like growth factor 1 (IGF1), plus two hormone binding proteins: IGF binding protein 3 (IGFbp3) and sex hormone binding globulin (SHBG) levels were measured at baseline, at end of month-1 and at end of month-2. This study failed to provide confirmatory evidence of lower serum E1 and E2 values due to green tea consumption. The E1 and E2 values declined in the group treated with EGCG but similar declines were also seen in the placebo group. The only treatment effect suggesting a protective effect against breast cancer was a decline in IGFbp3. |
| Keyword | phase II trial; hormone; Polyphenon E |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2101 |
| Rights | Ling, Chen |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Ling-2739 |
| Archival file | uscthesesreloadpub_Volume14/etd-Ling-2739.pdf |
Description
| Title | Page 1 |
| Full text | A RANDOMIZED, DOUBLE –BLIND, PLACEBO-CONTROLLED PHASE ΙΙ TRIAL TO EXAMINE THE EFFECT OF POLYPHENON E ON ENDOGENOUS HORMONE LEVELS by Chen Ling ______________________________________________________ A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATISTICS AND EPIDEMIOLOGY) May 2009 Copyright 2009 Chen Ling |
Comments
Post a Comment for Page 1
