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THE ADRB3 TRP64ARG VARIANT AND OBESITY IN AFRICAN AMERICAN BREAST CANCER CASES
by
Xuejun Li
____________________________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2006
Copyright 2006 Xuejun Li
Object Description
| Title | The ADRB3 TRP64ARG variant and obesity in African American breast cancer cases |
| Author | Li, Xuejun |
| Author email | xuejunal@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2005-10-01 |
| Date submitted | 2006 |
| Restricted until | Unrestricted |
| Date published | 2006-11-14 |
| Advisor (committee chair) | McKean-Cowdin, Roberta |
| Advisor (committee member) |
Gauderman, Jim Gilliland, Frank |
| Abstract | Weight is an important determinant of disease-free survival in women diagnosed with breast cancer. ADRB3 is a candidate obesity gene that plays an active role in lipid metabolism in visceral fat tissue. A missense change at codon 64 of this gene has been associated with obesity-related phenotypes and may be relevant to weight and obesity among breast cancer cases. The current analysis includes 219 women from the Los Angeles component of the HEAL Study -- a population-based cohort of African-American (AA) breast cancer patients. We found AA women who were homozygous for the ADRB3 wild type allele had significantly higher mean visceral fat levels than women who carried the variant (p=0.04) and were significantly more likely to have a BMI >30 kg/m2 (OR=2.1, 95% CI 1.1-4.2). The association with BMI was most pronounced among women who were premenopausal, who had taken chemotherapy, or who were not physically active. |
| Keyword | ADRB3; obesity; African American women; HEAL study |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m130 |
| Rights | Li, Xuejun |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Li-20061114 |
| Archival file | uscthesesreloadpub_Volume23/etd-Li-20061114.pdf |
Description
| Title | Page 1 |
| Full text | THE ADRB3 TRP64ARG VARIANT AND OBESITY IN AFRICAN AMERICAN BREAST CANCER CASES by Xuejun Li ____________________________________________________________________ A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) December 2006 Copyright 2006 Xuejun Li |
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